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Journal of Biological Sciences

Year: 2008 | Volume: 8 | Issue: 4 | Page No.: 767-772
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Authors

Moazedi Ahmad Ali

Ehsani Vostacolaee Simin

Chinipardaz Rahim

Keywords

Research Article

Effect of Oral Aluminum Chloride Administration During Lactation on Short and Long-Term Memory of Their Offspring

Moazedi Ahmad Ali, Ehsani Vostacolaee Simin and Chinipardaz Rahim
To study the relationship between aluminum chloride (AlCl3) and memory of their offspring male. Five groups of adult Wistar rats (200 ± 30) were taken for this experiment. Female rats were concurrently exposed (0, 200, 400, 600 and 800 mg/kg/day) of aluminum administered as AlCl3 in drinking water for two weeks. Forty-five after birth, a shuttle box was used to test memory. This experiment showed that maternal dietary exposure Alcl3 (200, 400 and 600 mg/kg/day) doses after two weeks during lactation, there were no different on the working memory of their offspring for any of groups. But rat which received AlCl3 800 mg/kg/day during lactation, has shown significant impairment in working memory of their offspring (p < 0.001) (p < 0.05). This study has demonstrated that (200, 400 and 600 mg/kg/day) AlCl3 consumption for two weeks during lactation had no effect. But consumption of AlCl3 800 mg/kg/day during lactation, can impairment in (short-term and long-term) memory of their offspring.
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