The Antiproliferative Activity of Flavanoidal Fraction of Indigofera tinctoria is Through Cell Cycle Arrest and Apoptotic Pathway in A-549 Cells

Research Article

**The Antiproliferative Activity of Flavanoidal Fraction of Indigofera tinctoria is Through Cell Cycle Arrest and Apoptotic Pathway in A-549 Cells**

Thiruvanmiyoor Ravichandran Kameswaran and Ravichandran Ramanibai

The aerial parts of the plant was investigated for its antiproliferative activity in human Non Small Cell Lung Cancer cells A-549. The results showed that the flavanoidal fraction of methanolic extract of the aerial parts of the plant inhibited the proliferation of A-549 cells as measured by MTT assay. Flow cytometric analysis showed that flavanoidal fraction of methanolic extract of I. tinctoria blocked cell cycle progression in G0/G1 phase. In addition flavanoidal fraction of methanolic extract of I. tinctoria induced A-549 cell apoptosis as determined by propidium iodide staining. We suggests that flavanoidal fraction of methanolic extract of I. tinctoria activity might be potentially contribute to its overall chemo preventive effect against lung cancer and can possibly be considered for future therapeutic application.

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Thiruvanmiyoor Ravichandran Kameswaran and Ravichandran Ramanibai, 2008. The Antiproliferative Activity of Flavanoidal Fraction of Indigofera tinctoria is Through Cell Cycle Arrest and Apoptotic Pathway in A-549 Cells. Journal of Biological Sciences, 8: 584-590.

DOI: 10.3923/jbs.2008.584.590

URL: https://scialert.net/abstract/?doi=jbs.2008.584.590

Journal of Biological Sciences

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Thiruvanmiyoor Ravichandran Kameswaran

Ravichandran Ramanibai

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Research Article

**The Antiproliferative Activity of Flavanoidal Fraction of Indigofera tinctoria is Through Cell Cycle Arrest and Apoptotic Pathway in A-549 Cells**

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