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Journal of Biological Sciences
  Year: 2008 | Volume: 8 | Issue: 1 | Page No.: 149-154
DOI: 10.3923/jbs.2008.149.154
In vitro Antibacterial Regimes of Crude Aqueous and Acetone Extracts of Garcinia kola Seeds
T. Sibanda and A.I. Okoh

Abstract:
Aqueous and acetone extracts of Garcinia kola seeds were screened for activity against 27 bacterial isolates at 30 and 10 mg mL-1, respectively. The aqueous extracts showed activity mainly against Gram positive organisms with MIC values ranging from 5-20 mg mL-1. The acetone extract showed activity against both Gram negative and Gram positive organisms with MIC values ranging from 10-0.156 mg mL-1. The bactericidal activity of the acetone extract was evaluated against Staphylococcus aureus ATCC6538 and Proteus vulgaris CSIR0030 by time kill assay. The extract showed rapid bactericidal activity achieving a 3.097 log10 reduction in counts within 4 h at 0.3125 mg mL-1 against Staph. aureus ATCC6538 and complete eradication of the organism in 8 h at 2× and 3× MIC levels. A 1.582 log10 reduction in counts was observed against P. vulgaris CSIR0030 at 5 mg mL-1 after 1 h of exposure and a complete eradication was observed in 2 h. We propose that acetone extract of Garcinia kola seeds possess strong bactericidal activities and can be chemotherapeutically useful in the treatment of bacterial infections in humans.
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How to cite this article:

T. Sibanda and A.I. Okoh , 2008. In vitro Antibacterial Regimes of Crude Aqueous and Acetone Extracts of Garcinia kola Seeds. Journal of Biological Sciences, 8: 149-154.

DOI: 10.3923/jbs.2008.149.154

URL: https://scialert.net/abstract/?doi=jbs.2008.149.154

 
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