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| Potential Hepatoprotective Effect of Aqueous Extract of Gracilaria
corticata in AFB1 Induced Hepatotoxicity in Wistar Rats |
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N. Manoharan,
P. Sampathkumar,
B. Dheeba,
S. Sheikabdulla,
G. Vinothprasanna,
R. Vinothkannan,
S. Kalavathy,
A. Vijayaanand and A. Shanmugasundaram |
Abstract:
The hepatoprotective activity of the marine algae
Gracilaria corticata was investigated against aflatoxin B1
(AFB1) induced hepatotoxicity. AFB1 (1 ppm) induced
hepatic damage was studied by assessing parameters such as body weight
gain, liver weight, total protein, albumin and enzyme markers viz.,
transaminases (SGOT and SGPT), Lactate dehydrogenase (LDH) and alkaline
phosphatase (ALP). The effect of co-administration of aqueous extract
of G. corticata on the above parameter was further investigated.
Hepatic damage was evidenced by significant (p<0.05) decreased level
of body weight gain, liver weight, total protein and albumin. Co administration
of rats with the aqueous extract of G. corticata showed a tendency
to attain near normalcy. Elevated levels of total bilirubin, SGOT, SGPT,
LDH and ALP in aflatoxin B1 intoxicated rats were restored
to normal level in the rats treated with aqueous extract (250 mg kg-1
body weight) and aflatoxin B1. Thus the study substantiates
the hepatoprotective potential of aqueous extract of G. corticata.
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How to cite this article:
N. Manoharan, P. Sampathkumar, B. Dheeba, S. Sheikabdulla, G. Vinothprasanna, R. Vinothkannan, S. Kalavathy, A. Vijayaanand and A. Shanmugasundaram, 2008. Potential Hepatoprotective Effect of Aqueous Extract of Gracilaria
corticata in AFB1 Induced Hepatotoxicity in Wistar Rats. Journal of Biological Sciences, 8: 1352-1355.
DOI: 10.3923/jbs.2008.1352.1355
URL: https://scialert.net/abstract/?doi=jbs.2008.1352.1355
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