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Journal of Biological Sciences

Year: 2008 | Volume: 8 | Issue: 6 | Page No.: 1092-1095
DOI: 10.3923/jbs.2008.1092.1095

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Authors


S. Niknazar


S. Farajnia


N. Ahmady Asl


M.H. Alipur

Country: Iran

L. Mohammadnejad


H. Rezaee


Keywords


  • Endothelin-1
  • treadmill exercise
  • lung
  • RT-PCR
Research Article

The Effects of Three Months Exercise on Expression of Endothelin-1 in the Lung Tissue

S. Niknazar, S. Farajnia, N. Ahmady Asl, M.H. Alipur, L. Mohammadnejad and H. Rezaee
In the present study, the effects of three months exercise training in the expression of ET-1 gene in lungs tissue were investigated. Twenty male Wistar rats (235±27 g) were maintained on a 12:12 h light-dark cycleand received food and water. Animals were randomly divided into two groups (n = 10). Rats in test group ran on a treadmill for 60 min at a speed of 25 m min-1 daily for 3 months. Total RNA was extracted from the lung tissue and the expression of ET-1 mRNA was assessed by RT-PCR. Analysis of results indicated that the expression of ET-1 mRNA in the lung was significantly higher in the exercise rats than in the control rats (p<0.05). The results of this study were shown that three months exercise increased the ET-1 expression in the lungs that could increase the blood flow of lungs via ETB receptor.
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How to cite this article

S. Niknazar, S. Farajnia, N. Ahmady Asl, M.H. Alipur, L. Mohammadnejad and H. Rezaee, 2008. The Effects of Three Months Exercise on Expression of Endothelin-1 in the Lung Tissue. Journal of Biological Sciences, 8: 1092-1095.

DOI: 10.3923/jbs.2008.1092.1095

URL: https://scialert.net/abstract/?doi=jbs.2008.1092.1095

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