The Effects of Three Months Exercise on Expression of Endothelin-1 in the Lung Tissue


	Journal of Biological Sciences
	Year: 2008 \| Volume: 8 \| Issue: 6 \| Page No.: 1092-1095 DOI: 10.3923/jbs.2008.1092.1095

The Effects of Three Months Exercise on Expression of Endothelin-1 in the Lung Tissue

S. Niknazar, S. Farajnia, N. Ahmady Asl, M.H. Alipur, L. Mohammadnejad and H. Rezaee

Abstract: In the present study, the effects of three months exercise training in the expression of ET-1 gene in lungs tissue were investigated. Twenty male Wistar rats (235±27 g) were maintained on a 12:12 h light-dark cycleand received food and water. Animals were randomly divided into two groups (n = 10). Rats in test group ran on a treadmill for 60 min at a speed of 25 m min^-1 daily for 3 months. Total RNA was extracted from the lung tissue and the expression of ET-1 mRNA was assessed by RT-PCR. Analysis of results indicated that the expression of ET-1 mRNA in the lung was significantly higher in the exercise rats than in the control rats (p<0.05). The results of this study were shown that three months exercise increased the ET-1 expression in the lungs that could increase the blood flow of lungs via ETB receptor.

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How to cite this article:

S. Niknazar, S. Farajnia, N. Ahmady Asl, M.H. Alipur, L. Mohammadnejad and H. Rezaee, 2008. The Effects of Three Months Exercise on Expression of Endothelin-1 in the Lung Tissue. Journal of Biological Sciences, 8: 1092-1095.

DOI: 10.3923/jbs.2008.1092.1095

URL: https://scialert.net/abstract/?doi=jbs.2008.1092.1095

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