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Journal of Biological Sciences

Year: 2008 | Volume: 8 | Issue: 6 | Page No.: 1092-1095
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Authors

S. Niknazar

S. Farajnia

N. Ahmady Asl

M.H. Alipur

L. Mohammadnejad

H. Rezaee

Keywords

In the present study, the effects of three months exercise training in the expression of ET-1 gene in lungs tissue were investigated. Twenty male Wistar rats (235±27 g) were maintained on a 12:12 h light-dark cycleand received food and water. Animals were randomly divided into two groups (n = 10). Rats in test group ran on a treadmill for 60 min at a speed of 25 m min-1 daily for 3 months. Total RNA was extracted from the lung tissue and the expression of ET-1 mRNA was assessed by RT-PCR. Analysis of results indicated that the expression of ET-1 mRNA in the lung was significantly higher in the exercise rats than in the control rats (p<0.05). The results of this study were shown that three months exercise increased the ET-1 expression in the lungs that could increase the blood flow of lungs via ETB receptor.
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