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Journal of Biological Sciences
  Year: 2008 | Volume: 8 | Issue: 6 | Page No.: 1087-1091
DOI: 10.3923/jbs.2008.1087.1091
The Structural Characterization of Recombinant Human Interferon Gamma
N. MalekSabet, M.R. Masoumian, M.A. Nasiri-Khalili, N. Maghsoudi, H. Sami, A. Saeedinia and R. Mohammadi

Abstract:
The recombinant human interferon gamma (rhIFN-γ) that is produced in E. coli by a method based on recombinant DNA technology, increases macrophage cytotoxicity. In this study to evaluate the structural characterization of rhIFN-γ, considered two conditions: fresh sample (4°C) and old sample (6 months in 25°C) of rhIFN-γ. Fresh sample (4°C) and old sample (6 months in 25°C) analyzed by analytical methods for determination of biological activity and structural analysis (deamidated and oxidized, heterodimers, monomer and aggregates, covalent dimer and SDS-PAGE). The structural characterization of them was compared.
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How to cite this article:

N. MalekSabet, M.R. Masoumian, M.A. Nasiri-Khalili, N. Maghsoudi, H. Sami, A. Saeedinia and R. Mohammadi, 2008. The Structural Characterization of Recombinant Human Interferon Gamma. Journal of Biological Sciences, 8: 1087-1091.

DOI: 10.3923/jbs.2008.1087.1091

URL: https://scialert.net/abstract/?doi=jbs.2008.1087.1091

 
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