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Journal of Biological Sciences

Year: 2008 | Volume: 8 | Issue: 6 | Page No.: 1087-1091
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Authors

N. MalekSabet

M.R. Masoumian

M.A. Nasiri-Khalili

N. Maghsoudi

H. Sami

A. Saeedinia

R. Mohammadi

Keywords

The recombinant human interferon gamma (rhIFN-γ) that is produced in E. coli by a method based on recombinant DNA technology, increases macrophage cytotoxicity. In this study to evaluate the structural characterization of rhIFN-γ, considered two conditions: fresh sample (4°C) and old sample (6 months in 25°C) of rhIFN-γ. Fresh sample (4°C) and old sample (6 months in 25°C) analyzed by analytical methods for determination of biological activity and structural analysis (deamidated and oxidized, heterodimers, monomer and aggregates, covalent dimer and SDS-PAGE). The structural characterization of them was compared.
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