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Journal of Biological Sciences

Year: 2007 | Volume: 7 | Issue: 3 | Page No.: 575-578
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Authors

I.A. Oyemitan

E.O. Iwalewa

O.E. Ukponmwan

R.O. Akomolafe

O.M. Daniyan

Keywords

The aim of this study is to evaluate and confirm the possible neurotransmitter(s) involved in artemether-induced behavioural syndrome in rats. Rats were administered with 0.2 mL kg-1 normal saline and varying doses of i.m artemether (25, 50 and 100 mg kg-1) for 6 consecutive days. Neurotoxic symptoms were observed with 50 and 100 mg kg-1 from day 6 upward. However, the behavioural syndrome was induced consistently at 100 mg kg-1 x 6 days specifically between day 8 and 9. Another group of rats were pre-treated with various drugs (apomorphine, morphine, naltrexone, diazepam, cyproheptadine and clozapine) 30 min prior i.m artemether for 6 consecutive days and the various symptoms were observed in each rat. Finally, rats exhibiting the behavious were subjected to the characteristic 5-HT testing. At 50 mg kg-1 x 6 days, artemether induced mild symptoms. At 100 mg kg-1 x 6 days, artemether induced consistent behavioural symptoms. Pretreatment with various drugs did not suppress the syndrome at day 8, but cyproheptadine and clozapine suppressed the syndrome significantly at day 6. Behavioural testing also confirmed the characteristic 5-HT syndrome in rats exhibiting the symptoms. The result confirmed the involvement and possibly by an enhanced 5-HT neurotransmission in the mediation of the behavioural syndrome due to sub-chronic administration of i.m artemether in rats.
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