• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. Journal of Biological Sciences
  2. Vol 7 (3), 2007
  3. 575-578
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

Journal of Biological Sciences

Year: 2007 | Volume: 7 | Issue: 3 | Page No.: 575-578
DOI: 10.3923/jbs.2007.575.578

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 171

Authors


I.A. Oyemitan


E.O. Iwalewa


O.E. Ukponmwan


R.O. Akomolafe


O.M. Daniyan


Keywords


  • Artemether
  • behavioural activities
  • 5-HT (Serotonin) involvement
Research Article

The Involvement of Serotonin in Artemether-Induced Behavioural Activities

I.A. Oyemitan, E.O. Iwalewa, O.E. Ukponmwan, R.O. Akomolafe and O.M. Daniyan
The aim of this study is to evaluate and confirm the possible neurotransmitter(s) involved in artemether-induced behavioural syndrome in rats. Rats were administered with 0.2 mL kg-1 normal saline and varying doses of i.m artemether (25, 50 and 100 mg kg-1) for 6 consecutive days. Neurotoxic symptoms were observed with 50 and 100 mg kg-1 from day 6 upward. However, the behavioural syndrome was induced consistently at 100 mg kg-1 x 6 days specifically between day 8 and 9. Another group of rats were pre-treated with various drugs (apomorphine, morphine, naltrexone, diazepam, cyproheptadine and clozapine) 30 min prior i.m artemether for 6 consecutive days and the various symptoms were observed in each rat. Finally, rats exhibiting the behavious were subjected to the characteristic 5-HT testing. At 50 mg kg-1 x 6 days, artemether induced mild symptoms. At 100 mg kg-1 x 6 days, artemether induced consistent behavioural symptoms. Pretreatment with various drugs did not suppress the syndrome at day 8, but cyproheptadine and clozapine suppressed the syndrome significantly at day 6. Behavioural testing also confirmed the characteristic 5-HT syndrome in rats exhibiting the symptoms. The result confirmed the involvement and possibly by an enhanced 5-HT neurotransmission in the mediation of the behavioural syndrome due to sub-chronic administration of i.m artemether in rats.
PDF Fulltext XML References Citation

How to cite this article

I.A. Oyemitan, E.O. Iwalewa, O.E. Ukponmwan, R.O. Akomolafe and O.M. Daniyan, 2007. The Involvement of Serotonin in Artemether-Induced Behavioural Activities. Journal of Biological Sciences, 7: 575-578.

DOI: 10.3923/jbs.2007.575.578

URL: https://scialert.net/abstract/?doi=jbs.2007.575.578

Related Articles

Induction and Uncoupling of Rat Liver Mitochondria by Oral Administered Coartemether
Some Histological Observations and Microstructural Changes in the Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Artesunate Administration

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved