The Involvement of Serotonin in Artemether-Induced Behavioural Activities


	Journal of Biological Sciences
	Year: 2007 \| Volume: 7 \| Issue: 3 \| Page No.: 575-578 DOI: 10.3923/jbs.2007.575.578

The Involvement of Serotonin in Artemether-Induced Behavioural Activities

I.A. Oyemitan, E.O. Iwalewa , O.E. Ukponmwan , R.O. Akomolafe and O.M. Daniyan

Abstract: The aim of this study is to evaluate and confirm the possible neurotransmitter(s) involved in artemether-induced behavioural syndrome in rats. Rats were administered with 0.2 mL kg^-1 normal saline and varying doses of i.m artemether (25, 50 and 100 mg kg^-1) for 6 consecutive days. Neurotoxic symptoms were observed with 50 and 100 mg kg^-1 from day 6 upward. However, the behavioural syndrome was induced consistently at 100 mg kg^-1 x 6 days specifically between day 8 and 9. Another group of rats were pre-treated with various drugs (apomorphine, morphine, naltrexone, diazepam, cyproheptadine and clozapine) 30 min prior i.m artemether for 6 consecutive days and the various symptoms were observed in each rat. Finally, rats exhibiting the behavious were subjected to the characteristic 5-HT testing. At 50 mg kg^-1 x 6 days, artemether induced mild symptoms. At 100 mg kg^-1 x 6 days, artemether induced consistent behavioural symptoms. Pretreatment with various drugs did not suppress the syndrome at day 8, but cyproheptadine and clozapine suppressed the syndrome significantly at day 6. Behavioural testing also confirmed the characteristic 5-HT syndrome in rats exhibiting the symptoms. The result confirmed the involvement and possibly by an enhanced 5-HT neurotransmission in the mediation of the behavioural syndrome due to sub-chronic administration of i.m artemether in rats.

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How to cite this article:

I.A. Oyemitan, E.O. Iwalewa , O.E. Ukponmwan , R.O. Akomolafe and O.M. Daniyan , 2007. The Involvement of Serotonin in Artemether-Induced Behavioural Activities. Journal of Biological Sciences, 7: 575-578.

DOI: 10.3923/jbs.2007.575.578

URL: https://scialert.net/abstract/?doi=jbs.2007.575.578

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