Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
Journal of Biological Sciences
  Year: 2007 | Volume: 7 | Issue: 3 | Page No.: 575-578
DOI: 10.3923/jbs.2007.575.578
The Involvement of Serotonin in Artemether-Induced Behavioural Activities
I.A. Oyemitan, E.O. Iwalewa , O.E. Ukponmwan , R.O. Akomolafe and O.M. Daniyan

Abstract: The aim of this study is to evaluate and confirm the possible neurotransmitter(s) involved in artemether-induced behavioural syndrome in rats. Rats were administered with 0.2 mL kg-1 normal saline and varying doses of i.m artemether (25, 50 and 100 mg kg-1) for 6 consecutive days. Neurotoxic symptoms were observed with 50 and 100 mg kg-1 from day 6 upward. However, the behavioural syndrome was induced consistently at 100 mg kg-1 x 6 days specifically between day 8 and 9. Another group of rats were pre-treated with various drugs (apomorphine, morphine, naltrexone, diazepam, cyproheptadine and clozapine) 30 min prior i.m artemether for 6 consecutive days and the various symptoms were observed in each rat. Finally, rats exhibiting the behavious were subjected to the characteristic 5-HT testing. At 50 mg kg-1 x 6 days, artemether induced mild symptoms. At 100 mg kg-1 x 6 days, artemether induced consistent behavioural symptoms. Pretreatment with various drugs did not suppress the syndrome at day 8, but cyproheptadine and clozapine suppressed the syndrome significantly at day 6. Behavioural testing also confirmed the characteristic 5-HT syndrome in rats exhibiting the symptoms. The result confirmed the involvement and possibly by an enhanced 5-HT neurotransmission in the mediation of the behavioural syndrome due to sub-chronic administration of i.m artemether in rats.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Induction and Uncoupling of Rat Liver Mitochondria by Oral Administered Coartemether
  •    Some Histological Observations and Microstructural Changes in the Nissl Substances in the Cerebellar Cortex of Adult Wistar Rats following Artesunate Administration
How to cite this article:

I.A. Oyemitan, E.O. Iwalewa , O.E. Ukponmwan , R.O. Akomolafe and O.M. Daniyan , 2007. The Involvement of Serotonin in Artemether-Induced Behavioural Activities. Journal of Biological Sciences, 7: 575-578.

DOI: 10.3923/jbs.2007.575.578

URL: https://scialert.net/abstract/?doi=jbs.2007.575.578
 
COMMENT ON THIS PAPER
 
 
 

 
  Navigation
 
  Online First
  Current Issue
  Previous Issues
  Editorial Board
  Submit a Manuscript
  Guide to Authors
  Subscribe to E-alerts

  Indexed In
 
  AGRICOLA
  AGRIS
  ASCI-Database
  Asian Digital Library
  Cambridge Scientific Abstract
  EMBASE
  Google Scholar
  SCIMAGO

       

       

Science Alert
Curve Bottom