Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats

Research Article

**Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats**

J.K. Adesanwo, Y. Raji, S.B. Olaleye, S.A. Onasanwo, O.O. Fadare, O.O. Ige and O.O. Odusanya

The effect of Bryophyllum pinnatum leaves extract on indomethacin induced gastric ulceration was determined using 25 male albino rats. Animals were divided into 5 groups of 5 animals each. The control group received 0.5 mL of distilled water and varying doses of the extract were used for the remaining groups (10-40 mg kg^-1 body weight). The result showed a significant reduction (p<0.05) in incidence of ulceration and mean basal and histamine (1 mg kg^-1) stimulated gastric acid secretion in a dose dependent manner thus justifying the use of Bryophyllum pinnatum as an anti-ulcer agent in folklore medicine.

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J.K. Adesanwo, Y. Raji, S.B. Olaleye, S.A. Onasanwo, O.O. Fadare, O.O. Ige and O.O. Odusanya, 2007. Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats. Journal of Biological Sciences, 7: 409-412.

DOI: 10.3923/jbs.2007.409.412

URL: https://scialert.net/abstract/?doi=jbs.2007.409.412

Journal of Biological Sciences

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Authors

J.K. Adesanwo

Y. Raji

S.B. Olaleye

S.A. Onasanwo

O.O. Fadare

O.O. Ige

O.O. Odusanya

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Research Article

**Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats**

How to cite this article

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