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Journal of Biological Sciences
  Year: 2007 | Volume: 7 | Issue: 2 | Page No.: 409-412
DOI: 10.3923/jbs.2007.409.412
 
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Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats

J.K. Adesanwo, Y. Raji , S.B. Olaleye , S.A. Onasanwo , O.O. Fadare , O.O. Ige and O.O. Odusanya

Abstract:
The effect of Bryophyllum pinnatum leaves extract on indomethacin induced gastric ulceration was determined using 25 male albino rats. Animals were divided into 5 groups of 5 animals each. The control group received 0.5 mL of distilled water and varying doses of the extract were used for the remaining groups (10-40 mg kg-1 body weight). The result showed a significant reduction (p<0.05) in incidence of ulceration and mean basal and histamine (1 mg kg-1) stimulated gastric acid secretion in a dose dependent manner thus justifying the use of Bryophyllum pinnatum as an anti-ulcer agent in folklore medicine.
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How to cite this article:

J.K. Adesanwo, Y. Raji , S.B. Olaleye , S.A. Onasanwo , O.O. Fadare , O.O. Ige and O.O. Odusanya , 2007. Antiulcer Activity of Methanolic Extract of Bryophyllum pinnatum in Rats. Journal of Biological Sciences, 7: 409-412.

DOI: 10.3923/jbs.2007.409.412

URL: https://scialert.net/abstract/?doi=jbs.2007.409.412

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