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Journal of Biological Sciences
  Year: 2007 | Volume: 7 | Issue: 2 | Page No.: 321-326
DOI: 10.3923/jbs.2007.321.326
 
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Hypoglycemic Effect of Ficus microcarpa Leaves (Chinese Banyan) on Alloxan-induced Diabetic Rats
K. Asok Kumar, M. Uma Maheswari , A.T. Sivashanmugam , V. Subhadra Devi , N.V. Prasanth and T.K. Ravi

Abstract:
The ethanolic extract of Ficus microcarpa L. leaves (EEFML) was evaluated for its hypoglycaemic activity against alloxan-induced diabetes. Diabetes was induced by intraperitoneal injection of alloxan (150 mg kg-1, body weight). EEFML was administered at 100 and 200 mg kg-1 body weight orally for 14 days. The blood glucose was estimated on 0, 7 and 15 days of drug treatment. Glibenclamide (5 mg kg-1) served as positive control. Other parameters such as serum cholesterol, triglycerides, HDL, LDL, VLDL, liver antioxidant enzymes (CAT, SOD, GPx) and TBARS levels were also estimated. Biochemical observations were supplemented with histopathological examination of pancreas. Administration of 200 mg kg-1 of EEFML significantly (p<0.001) reduced the amount of blood glucose (101.5±8.58 mg dL-1) when compared to diabetic control (266.91±15.44 mg dL-1). A decrease in TBARS and an increase in GPx, SOD and CAT levels clearly demonstrated the antioxidant property of EEFML. An increase in HDL and reduction in triglycerides, total cholesterol, LDL and VLDL of EEFML-treated groups against diabetic control evidenced its hypolipoproteinemic activity. These results reveal the beneficial role of Ficus microcarpa leaves as a potential hypoglycaemic agent against alloxan-induced diabetes mellitus in rats, which may be attributed to the increased levels of antioxidant enzymes and also by preserving the pancreatic β-cell integrity as evidenced by histopathological studies.
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How to cite this article:

K. Asok Kumar, M. Uma Maheswari , A.T. Sivashanmugam , V. Subhadra Devi , N.V. Prasanth and T.K. Ravi , 2007. Hypoglycemic Effect of Ficus microcarpa Leaves (Chinese Banyan) on Alloxan-induced Diabetic Rats. Journal of Biological Sciences, 7: 321-326.

DOI: 10.3923/jbs.2007.321.326

URL: https://scialert.net/abstract/?doi=jbs.2007.321.326

 
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