
	Journal of Biological Sciences
	Year: 2007 \| Volume: 7 \| Issue: 8 \| Page No.: 1511-1519 DOI: 10.3923/jbs.2007.1511.1519

Antiangiogenic Effect of Rutin and its Regulatory Effect on the Production of VEGF, IL-1β and TNF-α in Tumor Associated Macrophages

C. Guruvayoorappan and Girija Kuttan

Abstract: The antiangiogenic activity of rutin was studied using in vivo as well as in vitro models. In vivo angiogenic activity was studied using B16F-10 melanoma cell-induced capillary formation in C57BL/6 mice. Administration of rutin significantly inhibited (43.35%) the number of tumor directed capillaries induced by injecting B16F-10 melanoma cells on the ventral side of C57BL/6 mice. Rutin at non-toxic concentrations (5-25 μg mL^-1) inhibited the vessel sprouting in rat aortic ring assay. Moreover, rutin was able to inhibit the proliferation, migration and capillary-like tube formation of human endothelial cells, the key steps of angiogenesis. Present studies using Tumor Associated Macrophages (TAMs) revealed that rutin could suppress the expression and production of VEGF and IL-1β and stimulate the production of TNF-α. Hence, the observed antiangiogenic activity of rutin is related to the regulation of these cytokines and growth factors by TAMs.

PDF Fulltext XML References Citation Report Citation

RELATED ARTICLES:

•	Protective Effect of Rutin Against Cadmium Induced Hepatotoxicity in Swiss Albino Mice

•	AT1 Receptors Activation Enhances the Expression of MMP-2, MMP-13 and VEGF but not MMP-9 in B16F10 Melanoma Cells

•	Chemical and Pharmacological Aspects of Toona (Meliaceae)

How to cite this article:

C. Guruvayoorappan and Girija Kuttan , 2007. Antiangiogenic Effect of Rutin and its Regulatory Effect on the Production of VEGF, IL-1β and TNF-α in Tumor Associated Macrophages. Journal of Biological Sciences, 7: 1511-1519.

DOI: 10.3923/jbs.2007.1511.1519

URL: https://scialert.net/abstract/?doi=jbs.2007.1511.1519

COMMENT ON THIS PAPER

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRICOLA
		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		EMBASE
		Google Scholar
		SCIMAGO

Science Alert