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Journal of Biological Sciences
  Year: 2006 | Volume: 6 | Issue: 3 | Page No.: 457-468
DOI: 10.3923/jbs.2006.457.468
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Hepatoprotective Activity of Allicin Against Carbon Tetrachloride Induced Hepatic Injury in Rats
Mohamed Nagui T. Attia and Magdy A. Ali

Oral treatment of rats with carbon tetrachloride (CCl4) have induced severe histopathological changes in the rat liver tissues characterized with proliferation of both inter and intralobular fibrous cells and around the branches of central vein (central cirrhosis), accompanied by fatty changes and ballooning degeneration or foamy cytoplasm of the hepatocytes, with focal necrosis and hypertrophy in some nuclei. Moreover, bile duct adenocarcinoma and tumor giant cells were prominent findings after four weeks of CCl4 treatment, where tumor cells showing pleomorphism and mitosis. In addition, telangectasis was seen in some cases especially in the subcapsular area of the liver. In this study, allicin, an organosulfer compound derived from garlic, was orally administered to a group of animals treated with CCl4 to inhibit the development of deleterious pathological changes in liver tissues of such intoxicated animals. Such group of animals, the liver specimens revealed focal areas of ballooned cells instead of diffused cells in group received CCl4 only. Also the central cirrhosis became dispersed instead of compact fibrous tissue. The perturbations changes were completely absent at the 4th week of administration and hepatocytes became more organized in hepatic cords. Bile duct adenocarcinoma and tumor cells that found in liver tissues of rats administered CCl4 alone for four weeks were not noticed when CCl4 given together with allicin.
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How to cite this article:

Mohamed Nagui T. Attia and Magdy A. Ali , 2006. Hepatoprotective Activity of Allicin Against Carbon Tetrachloride Induced Hepatic Injury in Rats. Journal of Biological Sciences, 6: 457-468.

DOI: 10.3923/jbs.2006.457.468








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