Physiological and Biochemical Alterations Induced by Subchronic Administration of Deltamethrin can be Possibly Corrected by Zinc Supplementation in Male Albino Rat


	Journal of Biological Sciences
	Year: 2005 \| Volume: 5 \| Issue: 2 \| Page No.: 211-221 DOI: 10.3923/jbs.2005.211.221

Physiological and Biochemical Alterations Induced by Subchronic Administration of Deltamethrin can be Possibly Corrected by Zinc Supplementation in Male Albino Rat

Emad El-Zayat , Manal El-Halwagy and Mohamed Farid

Abstract: The present study was conducted aiming to evaluate the possible effect of zinc supplementation as potent antioxidant in counteracting some of the physiological and biochemical alterations induced by subchronic administration of deltamethrin, a synthetic pyrethroid. Deltamethrin (DM) was injected in two doses in male albino rats in presence or absence of zinc. Many physiological and biochemical alteration have been induced by deltamethrin intoxication. Zinc supplementation proved a considerable ability to overcome some but not all of these alterations. The present investigation has also proved the possibility of using the isozyme electrophoretic patterns in testing for xenobiotic intoxication. The rate of gene expression of ALP₂ and ALP₃ isozymes, but not of ALP₁ are stimulated by DM intoxication. In case of ALP₃ the rate of gene expression seemed to be dose-dependent.

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How to cite this article:

Emad El-Zayat , Manal El-Halwagy and Mohamed Farid , 2005. Physiological and Biochemical Alterations Induced by Subchronic Administration of Deltamethrin can be Possibly Corrected by Zinc Supplementation in Male Albino Rat. Journal of Biological Sciences, 5: 211-221.

DOI: 10.3923/jbs.2005.211.221

URL: https://scialert.net/abstract/?doi=jbs.2005.211.221

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