The disposition of amoxycillun following intravenous (IV) and oral administration in camel was studied. The kinetic behavior of the drug was best described by two compartment open model. The half-life of distribution was 3.6±0.36 min for IV and 15.3±1.9 min for oral dosing. The half-life of elimination was 69.3±2.6 min for IV and 80.0±3.4 min for oral dosing. The mean peak plasma concentration after oral administration was 2.11±8.3 μg mL-1 detected at 2 h after drug administration and the bioavailability was 23.3%.