Research Article

Effect of Antibiotics on Pathophysiological Responses Induced in Mice Infected with Bordetella pertussis

Tasneem Shams Shaikh, Yasmeen Faiz Kazi, Imtiaz Ahmed and Mohammad R.A. Malik

This study was undertaken to evaluate and understand the effect of Augmentin, Erythromycin and Ofloxacin against Bordetella pertussis (B. pertussis) in murine model. Mice (BALB/C) were challenged with highly infective dose (2.2x10⁹CFU mL^-1) of B. pertussis and relatedness of pathophysiological responses, its intensity and the course was studied by monitoring the infection with mouse weight gain, temperature, induction of leukocytosis and lung score. Treatment was started giving first dose orally after an hour of infection, therapy was continued for six days. Antibiotics appeared to have provided benefit in decreasing the infection. Conclusively, Augmentin was found more effective than Erythromycin and Ofloxacin and indicated more persistent and potent efficacy in vivo.

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Tasneem Shams Shaikh, Yasmeen Faiz Kazi, Imtiaz Ahmed and Mohammad R.A. Malik, 2005. Effect of Antibiotics on Pathophysiological Responses Induced in Mice Infected with Bordetella pertussis. Journal of Biological Sciences, 5: 129-133.

DOI: 10.3923/jbs.2005.129.133

URL: https://scialert.net/abstract/?doi=jbs.2005.129.133

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Authors

Tasneem Shams Shaikh

Yasmeen Faiz Kazi

Imtiaz Ahmed

Mohammad R.A. Malik

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Research Article

Effect of Antibiotics on Pathophysiological Responses Induced in Mice Infected with Bordetella pertussis

How to cite this article

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