The Effect of Neem (Azadirachta indica) Aqueous Extract and Dietary Selenium on Distribution of Selenium in Liver Tissue During Hepatocarcinogenesis


	Journal of Biological Sciences
	Year: 2004 \| Volume: 4 \| Issue: 5 \| Page No.: 584-587 DOI: 10.3923/jbs.2004.584.587

The Effect of Neem (Azadirachta indica) Aqueous Extract and Dietary Selenium on Distribution of Selenium in Liver Tissue During Hepatocarcinogenesis

P. Hanachi , O. Fauziah , L.L. Nam , T.S. Tian , L.T. Peng , L.C. Weil and O.K. Ho

Abstract: This study aimed to determine the distribution of selenium in the liver of rats during hepatocarcinogenesis when neem aqueous extract and dietary selenium was supplemented. The selenium distribution of the 9 diethylnitrosamine (DEN) and 2-acetylaminofluorene (2-AAF) induced hepatocarcinogenesis in Sprague dawley male rats as well as the other 9 normal rats, which were supplemented with 5% (w/v) neem leaves aqueous extract, 1.85 mg L^-1 sodium selenate and tap water ad libitum according to the treatment groups for 10 weeks, were assessed with energy filter transmission electron microscope (EFTEM) by electron spectroscopic imaging (ESI)-3 window power law method. The result showed that the selenium distribution mean score in normal control group was the lowest and cancerous control group was the highest. However, the selenium distribution mean score in normal supplemented with 5% (w/v) neem leaves aqueous extract increased about 26% (p<0.05) compared to normal control group. This study suggested that neem leaves aqueous extract may be a potential primary chemopreventive agent rather than as secondary chemopreventive agent.

PDF References Citation Report Citation

How to cite this article:

P. Hanachi , O. Fauziah , L.L. Nam , T.S. Tian , L.T. Peng , L.C. Weil and O.K. Ho , 2004. The Effect of Neem (Azadirachta indica) Aqueous Extract and Dietary Selenium on Distribution of Selenium in Liver Tissue During Hepatocarcinogenesis . Journal of Biological Sciences, 4: 584-587.

DOI: 10.3923/jbs.2004.584.587

URL: https://scialert.net/abstract/?doi=jbs.2004.584.587

COMMENT ON THIS PAPER

	Full Name:
	E-mail:
	Comments:

Navigation


		Online First
		Current Issue
		Previous Issues
		Editorial Board
		Submit a Manuscript
		Guide to Authors
		Subscribe to E-alerts

Indexed In


		AGRICOLA
		AGRIS
		ASCI-Database
		Asian Digital Library
		Cambridge Scientific Abstract
		EMBASE
		Google Scholar
		SCIMAGO

Follow @scialert

Science Alert