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Journal of Biological Sciences
  Year: 2003 | Volume: 3 | Issue: 3 | Page No.: 298-304
DOI: 10.3923/jbs.2003.298.304
Anionic Hydrogels for Controlled Release of Transdermal Drug
Bashir Ahmad , Shumaila Bashir , Muhammad Nisar and M.B.Huglin

Anionic hydrogels, using Azo-iso butyronitrile as cross linker, with varying ionic moieties were prepared from N vinyl-2-Pyrrolidone/Methylene Succinic acid/water by heating them at different temperatures for different interval of times. Swelling/drug loading sensitivity with pH and ionic strength of the medium for these hydrogels were investigated. The results anticipate that hydrogels in the ratio of VP/IA 90:10 can be used for local therapeutic Transdermal drug delivery application of cationic, antifungal terbinafine hydrochloride (TER-HCl) in the concentration range of <100 mg ml G 1. In vitro studies in different buffer solutions indicated that pH and IA contents are two basic parameters which affect the release behaviour of the hydrogels.
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