
	Journal of Biological Sciences
	Year: 2002 \| Volume: 2 \| Issue: 3 \| Page No.: 145-150 DOI: 10.3923/jbs.2002.145.150

Synthesis and Evaluation of Biological and Pharmacological Activities of a Novel Acetyl-Derivative and Copper Complexes Tranexamic Acid

Muhammad Fayyaz Khan , Mohammad Farid Khan , Muhammad Ashfaq and Gul Majid Khan

Abstract: The objective of this study was to synthesize, characterize and evaluate biological and pharmacological activities of acetyl-substitutive derivative of Tranexamic acid (T.A) and their copper (II) complexes. N-Acetyltranexamic acid (A-2), Di-Tranexamate Diaquo Copper (II) (C-1) and Di-N-Acetyltranexamate Diaquo Copper (II) (C-3) were synthesized, using novel and reproducible procedures. These compounds were characterized using techniques like FTIR, Mass Spectroscopy and FT ¹H NMR. Different methods, reported in literature, have successfully been applied for qualitative and structural characterization of these compounds. C-1 showed unidentate bonding of carboxylic group to copper (II) while C-3 indicated bidentate bonding of carboxylate group to copper (II). Bioactivities of the compounds were carried out and the compounds exhibited excellent anti-tumor, significant analgesic and antifungal activities, leading to the conclusion that the derivatives and the complexes are more effective than their parent drug.

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How to cite this article:

Muhammad Fayyaz Khan , Mohammad Farid Khan , Muhammad Ashfaq and Gul Majid Khan , 2002. Synthesis and Evaluation of Biological and Pharmacological Activities of a Novel Acetyl-Derivative and Copper Complexes Tranexamic Acid. Journal of Biological Sciences, 2: 145-150.

DOI: 10.3923/jbs.2002.145.150

URL: https://scialert.net/abstract/?doi=jbs.2002.145.150

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