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Journal of Biological Sciences

Year: 2002 | Volume: 2 | Issue: 3 | Page No.: 145-150
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Authors

Muhammad Fayyaz Khan

Mohammad Farid Khan

Muhammad Ashfaq

Gul Majid Khan

Keywords

Research Article

Synthesis and Evaluation of Biological and Pharmacological Activities of a Novel Acetyl-Derivative and Copper Complexes Tranexamic Acid

Muhammad Fayyaz Khan, Mohammad Farid Khan, Muhammad Ashfaq and Gul Majid Khan
The objective of this study was to synthesize, characterize and evaluate biological and pharmacological activities of acetyl-substitutive derivative of Tranexamic acid (T.A) and their copper (II) complexes. N-Acetyltranexamic acid (A-2), Di-Tranexamate Diaquo Copper (II) (C-1) and Di-N-Acetyltranexamate Diaquo Copper (II) (C-3) were synthesized, using novel and reproducible procedures. These compounds were characterized using techniques like FTIR, Mass Spectroscopy and FT 1H NMR. Different methods, reported in literature, have successfully been applied for qualitative and structural characterization of these compounds. C-1 showed unidentate bonding of carboxylic group to copper (II) while C-3 indicated bidentate bonding of carboxylate group to copper (II). Bioactivities of the compounds were carried out and the compounds exhibited excellent anti-tumor, significant analgesic and antifungal activities, leading to the conclusion that the derivatives and the complexes are more effective than their parent drug.
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