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Journal of Applied Sciences

Year: 2019 | Volume: 19 | Issue: 4 | Page No.: 295-302
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Authors

Halla Mohamed Ragab

Halla Mohamed Ragab

Nabila Abd El Maksoud

Wafaa Abd Elaziz

Mohab H. Halim

Abdelkarim Kamel

Nour A. Abdulla

Keywords

Background and Objective: Hepatocellular carcinoma (HCC) has a rising prevalence rate worldwide. This study aims to appraise the serum survivin levels in malignant and nonmalignant chronic liver diseases (CLDs) patients and to elucidate a possible correlation between survivin and the clinico-pathological characteristics of the disease. Materials and Methods: During the period between May, 2016 and April, 2017, 96 chronic HCV patients with or without cirrhosis were included in this study. Persons with focal lesions in Ultrasound (US) and/or serum α-fetoprotein (AFP) level ≥200 ng mL–1 were investigated via triphasic computed tomography scanning (CT) and/or MRI. The levels of both survivin and AFP proteins in the serum were detected using ELISA. Results: Survivin was undetectable in 111 out of 120 serum samples (92. 5%). The survivin-positive samples (n = 9, median level, 81.46 pg mL–1, range, 9.38-223.81 pg mL–1) corresponded to 9 HCC patients who have multiple focal lesions. The sensitivity and specificity of survivin for selective detection of the HCC patients over the non-malignant CLD patients (HCV group and LC group) were 85.7 and 72%, respectively, at a cut-off value -26.196 pg mL–1. Also, using a combination of both markers improves the sensitivity, specificity, PPV, NPV to be 85.7, 95, 85.7 and 95% respectively. Conclusion: The previous results suggested that serum survivin could be a potential marker for detecting HCC development. Also, the combination between survivin and AFP is effective for increasing specificity for HCC diagnosis.
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How to cite this article

Halla Mohamed Ragab, Nabila Abd El Maksoud, Wafaa Abd Elaziz, Mohab H. Halim, Abdelkarim Kamel and Nour A. Abdulla, 2019. Combination of Serum Survivin and AFP as a Potential Marker in HCC Associated with Hepatitis C Viral Infection. Journal of Applied Sciences, 19: 295-302.

DOI: 10.3923/jas.2019.295.302

URL: https://scialert.net/abstract/?doi=jas.2019.295.302

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