
	Journal of Applied Sciences
	Year: 2019 \| Volume: 19 \| Issue: 4 \| Page No.: 287-294 DOI: 10.3923/jas.2019.287.294

Wound Healing and Blood Sugar Effect of Psidium guajava L. Leaves and Melastoma malabathricum L. Leaves on Rats with Diabetic Foot Ulcer

Tonny Cortis Maigoda

, Afriyana Siregar, Podojoyo , Sherly Ridhowati and Arie Krisnasary

Abstract: Background and Objective: Approximately 15% of people with DM will experience ulcers during their illness and 3-4% will have severe infections. This study aimed to examine the wound healing and blood sugar effect of Psidium guajava L. and Melastoma malabathricum L. (senduduk) leaves using diabetic foot ulcer rats. Materials and Methods: Diabetes were induced in the rat by single intraperitoneal injection of Alloxan monohydrate (120 mg kg^–1) and was injured by excision. The 30 rats were divided into following group: untreated control (group 1), group treated with metformin (group 2), group treated with senduduk leaves extract (group 3), group treated with guava leaves extract (group 4) and group treated with mixed extract of senduduk leaves and guava leaves (group 5). Blood sugar levels and wound area were measured before and after the intervention. Results: In vitro, the bioactive components of the mixed extract found were Flavonoid, Tannin, Saponin Steroid, total phenol 6.08%, quercetin 0.31 m g^–1 and high antioxidant activity >31.25 ppm in the mixed extract. In vivo analysis of rat group with mixed extract of senduduk leaves and guava leaves significantly (p<0.05) was able to decrease blood glucose level and reduce wound area in rat's foot and was better than other groups. Conclusion: Senduduk leaf extract and guava leaf extract significantly (p<0.05) reduce blood glucose levels and reduce the area of injury in rat feet.

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How to cite this article:

Tonny Cortis Maigoda, Afriyana Siregar, Podojoyo , Sherly Ridhowati and Arie Krisnasary, 2019. Wound Healing and Blood Sugar Effect of Psidium guajava L. Leaves and Melastoma malabathricum L. Leaves on Rats with Diabetic Foot Ulcer. Journal of Applied Sciences, 19: 287-294.

DOI: 10.3923/jas.2019.287.294

URL: https://scialert.net/abstract/?doi=jas.2019.287.294

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