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Journal of Applied Sciences

Year: 2015 | Volume: 15 | Issue: 6 | Page No.: 884-893
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Authors

Abdelwahed R. Sayed

Magdy M. Youssef

Yasair S. Al- Faiyz

Keywords

Research Article

Synthesis, Characterization and Biological Evaluation of Novel Thiadiazoline Sulfonamides and Metal Complexes

Abdelwahed R. Sayed, Magdy M. Youssef and Yasair S. Al- Faiyz
In the present work, we reported a novel thiadiazoline sulfonamide derivatives and their metal complexes were efficiently synthesized based on N-phenyl 2-pyridine carbohydrazonoyl halide. Synthesized compounds were elucidated by elemental analysis and spectral data. The newly synthesized compounds were evaluated for their in vitro antimicrobial activity against Gram negative (Escherichia coli and Pseudomonas aeruginosa), Gram positive (Staphylococcus aureus and Bacillus subtilis) bacterial strains and fungal strain Saccharomyces cerevisiae. The minimum inhibitory concentration of the synthesized compounds against various microorganisms was also determined. The synthesized thiadiazoline sulfonamide derivatives and metal complexes had superoxide dismutase-like activity and inhibited superoxide radical generation. Moreover, these organic compounds induced a wide range of DNA and protein degradation processes, based on agarose gel and sodium dodecyl sulfate-polyacrylamide gel electrophoresis analyses, respectively.
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