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Journal of Applied Sciences

Year: 2010 | Volume: 10 | Issue: 16 | Page No.: 1802-1805
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Authors

M.R. Sohrabi

M. Emrarian

M. Javanbakht

Keywords

Research Article

Application of H-Point Standard Additions Method for Simultaneous Determination of Levonorgestrel and Ethinylestradiol in Oral Contraceptives LD

M.R. Sohrabi, M. Emrarian and M. Javanbakht
The H-Point Standard Addition Method (HPSAM) has been applied for simultaneous determination of levonorgestrel (LEV) and ethinylestradiol (ETE) in contraceptive LD pill. LEV and ETE can be determined simultaneously in the range of 0.50-5.00 and 0.20-8.00 μg mL-1, respectively with satisfactory accuracy and precision. The proposed method has successfully been applied for the simultaneous determination of both compounds in several synthetic samples and Iranian commercial low-dose oral contraceptives. A Limit of Detection (LOD) of LEV and ETE was obtained 0.011 and 0.010 μg mL-1, respectively for synthetic samples. The standard error (Er) of LEV and ETE was obtained 3.33 and 4.16%, respectively. This procedure for simultaneous determination of LEV and ETE is sensitive and easy to perform.
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