Submit Manuscript

Journal of Applied Sciences

Year: 2009 | Volume: 9 | Issue: 19 | Page No.: 3407-3423
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 703

Search

Authors

Mustafa Abdo Saif Dehwah

Zhang Shuang

Wang Zhen Hua

Wang Min

Qing-Yang Huang

Keywords

The aim of this review was to discuss the current understanding of Type 2 Diabetes Mellitus (T2DM) genetic advance and aetiology. The T2DM is a genetically heterogeneous disease, with several relatively rare monogenic forms and a number of more common forms resulting from a complex interaction of genetic and environmental factors. Earlier studies using a candidate gene approach, family linkage studies and gene expression profiling uncovered a number of T2DM genes, but the genetic basis of common T2DM remained unknown. Recent years have seen a tremendous surge in our understanding of the genetics of T2DM by Genome-Wide Association Study (GWAS). Approximately 20 genes consistently associated with T2DM mainly implicate pancreatic β-cell function in the pathogenesis of T2DM.
PDF Fulltext XML References Citation

Leave a Comment

Your email address will not be published. Required fields are marked *