Submit Manuscript

Journal of Applied Sciences

Year: 2008 | Volume: 8 | Issue: 10 | Page No.: 1950-1955
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 536

Search

Authors

N.C. Obitte

H. Ezeiruaku

V.I. Onyishi

Keywords

Research Article

Preliminary Studies on Two Vegetable Oil Based Self Emulsifying Drug Delivery System (SEDDS) for the Delivery of Metronidazole, A Poorly Water Soluble Drug

N.C. Obitte, H. Ezeiruaku and V.I. Onyishi
A preliminary evaluation was carried out on metronidazole-loaded Self Emulsifying Drug Delivery System (SEDDS) using two vegetable oils-Palm Kernel Oil (PKO) and Palm Oil (PO). Purification of oils, drug solubility in the oils, pre/post formulation isotropicity tests, emulsification times and release studies of metronidazole from the SEDDS were carried out. Results indicated solubility values of 4.441 and 4.654%w/w, respectively for metronidazole in PKO and PO. Preformulation isotropicity test revealed that out of the 24 batches evaluated 10 of the SEDDS formulations containing different oil: surfactant ratios and PKO:PO admixtures were found to be isotropic after 5 h. However when the SEDDS were loaded with metronidazole there was a reduction in the number (to 7) of formulations that maintained isotropicity and stability after 72 h. All the batches had emulsification times of less than two minutes except batch 4D with oil:surfactant concentration of 50:50. The release profile showed that most of the formulations released 50% of drug in less than 8 min and 85% of drug in less than 30 min. We therefore conclude that SEDDS containing the two vegetable oils are potential alternatives when immediate release and delivery of metronidazole is the primary motivation.
PDF Fulltext XML References Citation

Related Articles

An Exhaustive Review on Solubility Enhancement for Hydrophobic Compounds by Possible Applications of Novel Techniques
Preparation and Evaluation of Gastroretentive Floating Pellets of Metronidazole Using Na-alginate and Hydroxyl Propyl Methyl Cellulose Polymers
Novel Integrated Approach for the Strategic Delivery of Hydrophobic Drugs by the Use of Self Emulsifying Drug Delivery System
In vivo Evaluation and Application of Central Composite Design in the Optimization of Amisulpride Self-Emulsifying Drug Delivery System

Leave a Comment

Your email address will not be published. Required fields are marked *