Subscribe Now Subscribe Today
Science Alert
 
Blue
   
Curve Top
Journal of Applied Sciences
  Year: 2007 | Volume: 7 | Issue: 1 | Page No.: 98-102
DOI: 10.3923/jas.2007.98.102
 
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

β-lactamase Molecular Classes Linked to Production Ways from Clinical Isolates in Burkina Faso/West Africa

Boukare Zeba, Jacques Simpore and Odile Germaine Nacoulma

Abstract:
β-lactamase production ways and inhibition patterns were investigated in cell suspensions of clinical isolates. The purpose of this research was prior to investigate the different β-lactamase molecular classes occurring in Burkina Faso owing to the local practice of β-lactam antibiotics. The use of specific inhibitors enabled to draw up an inhibition profile and consequently to assign an enzyme to accurate molecular class of β-lactamase. At the same time, β-lactamase expression ways were explored and correlated to the inhibition profiles. The current results pointed out two main groups of organisms. The first group of isolates secretes β-lactamases mainly by inducible way. Interestingly this bacterial group carries molecular class C of β-lactamase. The second group of isolates uses partial inducible and partial constitutive way for enzyme expression. These bacteria mostly carry molecular class A of β-lactamases. The sole exception encountered during these investigations is an organism, expressing exclusively by the constitutive way an enzyme that is found to belong to molecular class B of β-lactamases.
PDF Fulltext XML References Citation Report Citation
How to cite this article:

Boukare Zeba, Jacques Simpore and Odile Germaine Nacoulma, 2007. β-lactamase Molecular Classes Linked to Production Ways from Clinical Isolates in Burkina Faso/West Africa. Journal of Applied Sciences, 7: 98-102.

DOI: 10.3923/jas.2007.98.102

URL: https://scialert.net/abstract/?doi=jas.2007.98.102

COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 

Curve Bottom