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Journal of Applied Sciences

Year: 2007 | Volume: 7 | Issue: 18 | Page No.: 2598-2603
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Authors

M.O. Emeje

C.Y. Isimi

O.O. Kunle

S.I. Ofoefule

Keywords

Research Article

Effect of Polyethylene Glycol and Sodium Lauryl Sulphate on the Compaction Characteristics of Eudragit and Drug Release from its Matrix

M.O. Emeje, C.Y. Isimi, O.O. Kunle and S.I. Ofoefule
A study on the compaction characteristics of Eudragit l-100 both in the presence and in the absence of two commonly used additives, polyethylene glycol 6000 (PEG 6000) and Sodium Lauryl Sulphate (SLS) was done. Eudragit granules, with and without the additives and drug were prepared separately by the wet granulation method and compacts were made at varying compression pressures. Compaction characteristics using Kawakita and Heckel analysis revealed a concentration dependent effect of the additives on the compressibility of Eudragit granules, with 2.5% PEG 6000 producing the largest effect and 5.0% PEG 6000, the least. Irrespective of the concentration of PEG 6000, the yield value increased, while SLS either had no effect or decreased the yield value of Eudragit granules. The highest yield value of 21.69 kN was produced by formulations containing 2.5% PEG 6000. While in some cases, the effect of the additive was slight, in others, it was drastic. The extent and nature of the effect depended on both the type and concentration of the additive used. SLS was found to increase the deformation of Eudragit more than PEG 6000. In vitro dissolution in simulated intestinal fluid as indicated by time for 70% drug release (t70%) shows that both additives modulated drug release, with 2.5 % SLS and 5% PEG 6000 enhancing drug release, while 5% SLS resulted in retarded but erratic drug release. The results of this study show that additives such as PEG 6000 and SLS affect the compaction characteristics of Eudragit l-100 and these were also found to affect the retardant behavior of Eudragit.
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