The effect of the ethanolic extract of Citrus reticulata roots or the oleo-resin extract from Myrrh of Commiphora molmol tree (Mirazid) were studied as new antischistosomal drugs. The total protein and the different serum proteins namely albumin, prealbumin, β-lipoproteins, macroglobulins, α-1-acid glycoprotein, α-1-antitrypsin, cholinesterase, ceruloplasmin, haemopexin, haptoglobin, transferrin and lipoprotein were measured in both infected and treated mice. Also, liver function parameters; AST, ALT, ALP and total bilirubin were studied in the different mice groups. Besides, the parasitological parameters, egg count and worm burden were estimated. The results showed a significant reduction in all protein fraction concentrations in S. mansoni infected mice and elevation in the liver function parameters AST, ALT, ALP and bilirubin. Citrus reticulata extract and mirazid showed an improvement in all the previous parameters which confirmed the medical importance and curative effects of C. reticulata and mirazid against S. mansoni infection. Also, the results showed a noticeable reduction in ova count and worm burden.