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Journal of Applied Sciences
  Year: 2003 | Volume: 3 | Issue: 5 | Page No.: 317-330
DOI: 10.3923/jas.2003.317.330
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Effect of Permethrin Treatment on the Kidney of Newly Hatched Chick (Gallus domesticus)

Khurshid Anwar

Present study was aimed at investigating the toxic effects of permethrin on the kidney of newly hatched chicks developed from the eggs injected with a single sublethal doses (0.05 ml) of three different concentrations of permethrin insecticide (50, 100 and 200 ppm) on day ‘0 ’of incubation. Study included the estimation of a few enzyme activities and some biochemical constituents of kidney. Among enzymes, the activities of alkaline phosphatase, acid phosphatase, glutamate oxaloacetate transaminase and glutamate pyruvate transaminase were decreased, whereas, the activity of lactate dehydrogenase was increased. However, the activity of amylase remained unchanged. From among biochemical components glucose, glycogen, total protein, total lipids, cholesterol and uric acid contents elevated significantly at different dose levels whereas DNA and RNA contents were significantly reduced. Soluble protein, free amino acids (FAA) and urea contents remained unaltered. The common histopathological changes observed in the kidney sections from 100 and 200 ppm of permethrin-treated animals were tubular necrosis, reduction in the size of glomeruli as well as complete distortion of glomeruli in some sections accompanied by blood cell infiltration. Endothelial layer of Bowmann`s capsule and epithelial layer of glomeruli also showed severe damage. Histopathological changes were not observed in the kidney sections from the animals treated with 50 ppm of permethrin.
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How to cite this article:

Khurshid Anwar , 2003. Effect of Permethrin Treatment on the Kidney of Newly Hatched Chick (Gallus domesticus). Journal of Applied Sciences, 3: 317-330.

DOI: 10.3923/jas.2003.317.330






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