Studies were conducted to investigate the status of water bodies and their effect on human health in district Thar adjoining the Arabian sea coast, with very saline underground water. Water samples were collected from representative water bodies. In all, 95 water samples were collected from Dug wells (79), Hand/Motor pumps (9), water supply schemes (4), Canal water (2) and Tanko (1). The samples were analyzed for pH, Electrical Conductivity (EC), Dissolved Oxygen (DO), Total Suspended Solids (TSS), total coliform count, turbidity, alkalinity, hardness, phosphorus, copper, manganese, iron, zinc and sodium. It was found that most of the samples were contaminated with coliform bacteria, had higher TDS, pH, EC, hardness, alkalinity, iron and manganese and phosphate concentrations compared to the standard permissible limits.