• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Zoological Research
  2. Vol 15 (1), 2019
  3. 21-27
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Zoological Research

Year: 2019 | Volume: 15 | Issue: 1 | Page No.: 21-27
DOI: 10.3923/ijzr.2019.21.27

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 527

Authors


Ab Qayoom  Naik

Ab Qayoom Naik

LiveDNA: 91.23608

Vinoy Kumar  Shrivastava

Vinoy Kumar Shrivastava

LiveDNA: 91.28873

Keywords


  • organ weight
  • body weight
  • biochemical parameters
  • hematological parameters
  • Aspartame
Research Article

Effects of Short-term Consumption of Aspartame on Some Biochemical and Hematological Parameters in Female Swiss Albino Mice

Ab Qayoom Naik Ab Qayoom  Naik's LiveDNA and Vinoy Kumar Shrivastava Vinoy Kumar  Shrivastava's LiveDNA
Background and Objectives: Aspartame is a popular artificial sweetener used by a wide range of consumers as an alternative sweetener to reduce the calorie intake. Uncontrolled used of aspartame may have many unknown deleterious effects on the population. The objectives of the present study were to investigate the adverse effects of aspartame (ASP) on biochemical and hematological parameters of female Swiss albino mice. Materials and Methods: Adult female mice (n = 5 each group) were divided into two groups viz. control and treatment. Treatment group received aspartame orally (40 mg kg–1 or 0.04 mg g–1 b.wt./day), while control group received double distilled water only. Animal care and handling was performed according to the standard guidelines. After 30 days mice were sacrificed for estimation of alkaline phosphates, glutamic oxaloacetic transaminase, glutamic pyruvate transaminase and hematological parameters. Results: The results indicate that ASP exposure significantly (p<0.05) elevated alkaline phosphates (ALP), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT), while as a significant (p<0.05) decrease was observed in hematological parameters (i.e.) white blood cells (WBCs), red blood cells (RBCs), hemoglobin (Hb) percentage as well as total protein content, in case of ASP treated mice compared to the control group. Creatinine content was increased in case of ASP treated mice as compared to control. Conclusion: The observed changes show that ASP consumption may have deleterious effects. Therefore, the current study indicates that consumption of ASP was harmful to mice in relation to hematological and biochemical analysis and needs more scientific research to investigate its effects on other parameters.
PDF Fulltext XML References Citation

How to cite this article

Ab Qayoom Naik and Vinoy Kumar Shrivastava, 2019. Effects of Short-term Consumption of Aspartame on Some Biochemical and Hematological Parameters in Female Swiss Albino Mice. International Journal of Zoological Research, 15: 21-27.

DOI: 10.3923/ijzr.2019.21.27

URL: https://scialert.net/abstract/?doi=ijzr.2019.21.27

Related Articles

Health Implications Associated with Aspartame Consumption: A Substantial Review

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved