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International Journal of Zoological Research

Year: 2019 | Volume: 15 | Issue: 1 | Page No.: 21-27
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Authors

Ab Qayoom Naik

Ab Qayoom Naik

Vinoy Kumar Shrivastava

Vinoy Kumar Shrivastava

Keywords

Research Article

Effects of Short-term Consumption of Aspartame on Some Biochemical and Hematological Parameters in Female Swiss Albino Mice

Ab Qayoom Naik Ab Qayoom Naik's LiveDNA and Vinoy Kumar Shrivastava Vinoy Kumar Shrivastava's LiveDNA
Background and Objectives: Aspartame is a popular artificial sweetener used by a wide range of consumers as an alternative sweetener to reduce the calorie intake. Uncontrolled used of aspartame may have many unknown deleterious effects on the population. The objectives of the present study were to investigate the adverse effects of aspartame (ASP) on biochemical and hematological parameters of female Swiss albino mice. Materials and Methods: Adult female mice (n = 5 each group) were divided into two groups viz. control and treatment. Treatment group received aspartame orally (40 mg kg–1 or 0.04 mg g–1 b.wt./day), while control group received double distilled water only. Animal care and handling was performed according to the standard guidelines. After 30 days mice were sacrificed for estimation of alkaline phosphates, glutamic oxaloacetic transaminase, glutamic pyruvate transaminase and hematological parameters. Results: The results indicate that ASP exposure significantly (p<0.05) elevated alkaline phosphates (ALP), glutamic oxaloacetic transaminase (GOT) and glutamic pyruvate transaminase (GPT), while as a significant (p<0.05) decrease was observed in hematological parameters (i.e.) white blood cells (WBCs), red blood cells (RBCs), hemoglobin (Hb) percentage as well as total protein content, in case of ASP treated mice compared to the control group. Creatinine content was increased in case of ASP treated mice as compared to control. Conclusion: The observed changes show that ASP consumption may have deleterious effects. Therefore, the current study indicates that consumption of ASP was harmful to mice in relation to hematological and biochemical analysis and needs more scientific research to investigate its effects on other parameters.
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