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International Journal of Zoological Research
  Year: 2018 | Volume: 14 | Issue: 1 | Page No.: 21-29
DOI: 10.3923/ijzr.2018.21.29
Roles of Inducible Nitric Oxide Synthase and Interleukin-17 in Mice Experimentally Infected with Trypanosoma evansi
Bahaa EL-Deen Wadea El-Aswad, Amira Fathy Abd El-Atty, Manal Ahmed El-Melegy, Raafat Mohamed Shaapan , Amany Fawzy Atia, Noha Ahmed El Kaddy and Mohamed Mohamed Abd El-Ghaffar

Abstract:
Background and Objective: A zoonotic Trypanosoma evansi (T. evansi ) has the widest range and geographical distribution attributed to the mechanical transmission by many vectors. Inducible nitric oxide synthase (iNOS) activation by interleukin-17 (IL-17) were expressed in mice experimentally infected with T. evansi in addition to detection of serum level of IL-17 for better understanding the roles of iNOS and IL-17 in controlling this protozoan infection. Materials and Methods: Infected group (I) mice were injected with 4.5×105 trypomastigotes intraperitoneally, subdivided into I-3, I-5, I-10 and I-20 subgroups (10 mice, each), then sacrificed at 3, 5, 10 and 20 days post infection (p.i.), respectively, whereas control group mice (C) were injected with saline, subdivided into C-3, C-5, C-10 and C-20 subgroups (6 mice, each) and sacrificed along the parallel infected subgroup one. Results: iNOS was immunohistochemically detected with more expression in brain and the IL-17 revealed more in spleen than liver or brain, also its serum level increased significantly with progression of the infection. There was a negative correlation between parasitemia and either iNOS or IL-17. Conclusion: Trypanosoma evansi infection caused increasing both IL-17 and iNOS expression which both were coinciding with a low number of trypomastigotes referring strongly to their roles in limiting the infection.
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How to cite this article:

Bahaa EL-Deen Wadea El-Aswad, Amira Fathy Abd El-Atty, Manal Ahmed El-Melegy, Raafat Mohamed Shaapan, Amany Fawzy Atia, Noha Ahmed El Kaddy and Mohamed Mohamed Abd El-Ghaffar, 2018. Roles of Inducible Nitric Oxide Synthase and Interleukin-17 in Mice Experimentally Infected with Trypanosoma evansi. International Journal of Zoological Research, 14: 21-29.

DOI: 10.3923/ijzr.2018.21.29

URL: https://scialert.net/abstract/?doi=ijzr.2018.21.29

 
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