Subscribe Now Subscribe Today
Science Alert
 
FOLLOW US:     Facebook     Twitter
Blue
   
Curve Top
International Journal of Zoological Research
  Year: 2015 | Volume: 11 | Issue: 1 | Page No.: 9-18
DOI: 10.3923/ijzr.2015.9.18
Berberine Improves Kidney Injury Following Renal Ischemia Reperfusion in Rats
Firouzeh Gholampour, Seyed Moslem Fatemi Moghadam and Seyed Mohammad Owji

Abstract:
This study investigated the effect of berberine on the renal dysfunction and histological damage induced by renal ischaemia/reperfusion at an early stage. There were four groups (n = 7). In Ber+I/R group, rats received berberine (Ber; 15 mg kg-1 day-1) orally for 7 days before induction of ischemia. The I/R group received distilled water orally for 7 days. In sham and Ber+sham groups, that renal arteries were not occluded, distilled water and berberin (15 mg kg-1 day-1), respectively were administered orally for 7 days before surgery. Renal ischemia was induced by occlusion of both renal arteries for 45 min followed by 24 h of reperfusion. Blood samples were collected for biochemical analysis and finally the left kidney was preserved for future histological examination. The renal ischaemic challenge resulted in major histological damages of the kidney which were associated with increased levels of creatinine and Blood Urea Nitrogen (BUN) at the end of reperfusion period. In Ber+I/R group, the histological damage to the kidney was improved along with increased in plasma creatinine and BUN being smaller than those of the non-treated rats. Berberine exhibited an ameliorative effect against renal ischemia/reperfusion-induced lesions.
PDF Fulltext XML References Citation Report Citation
 RELATED ARTICLES:
  •    Renoprotective Effect of Date Fruit Extract on Ochratoxin (A) Induced-oxidative Stress in Distal Tubules of Rat: A Light and Electron Microscopic Study
  •    Soybean Extract Antioxidant Protective Activity Against Copper-Induced Cytotoxicity
  •    Hyperlipidemia Enhanced Oxidative Stress and Inflammatory Response Evoked by Renal Ischemia/Reperfusion Injury
  •    Antioxidant Potential, Total Phenolic and Flavonoid Contents from the Stem Bark of Guazuma ulmifolia Lam.
How to cite this article:

Firouzeh Gholampour, Seyed Moslem Fatemi Moghadam and Seyed Mohammad Owji, 2015. Berberine Improves Kidney Injury Following Renal Ischemia Reperfusion in Rats. International Journal of Zoological Research, 11: 9-18.

DOI: 10.3923/ijzr.2015.9.18

URL: https://scialert.net/abstract/?doi=ijzr.2015.9.18

 
COMMENT ON THIS PAPER
 
 
 

 

 
 
 
 
 
 
 
 
 

 
 
 
 
 
 
 
 
 
 
 

       

       

Curve Bottom