• [email protected]
  • +971 507 888 742
Submit Manuscript
SciAlert
  • Home
  • Journals
  • Information
    • For Authors
    • For Referees
    • For Librarian
    • For Societies
  • Contact
  1. International Journal of Zoological Research
  2. Vol 9 (2), 2013
  3. 58-65
  • Online First
  • Current Issue
  • Previous Issues
  • More Information
    Aims and Scope Editorial Board Guide to Authors Article Processing Charges
    Submit a Manuscript

International Journal of Zoological Research

Year: 2013 | Volume: 9 | Issue: 2 | Page No.: 58-65
DOI: 10.3923/ijzr.2013.58.65

Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend



Total views 191

Authors


F. Gholampour

Country: Iran

S.M. Owji

Country: Iran

Keywords


  • congestion
  • liver
  • Rosa canina
  • ischaemia/reperfusion
  • creatinine
Research Article

Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats

F. Gholampour and S.M. Owji
Recent studies have shown remote effects of renal Ischemia/Reperfusion (I/R) injury on the liver. Furthermore, I/R injury is correlated with the generation of Reactive Oxygen Species (ROS). This study investigated the effect of Rosa canina on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion at an early stage. There were three groups (n = 10), in which rats received orally 7 days before induction of ischemia, extract of Rosa canina (500 mg kg-1) in RC+I/R group and distilled water in I/R group. In sham group, the renal arteries were not occluded and distilled water was administered orally 7 days before surgery. Renal ischemia was induced by both renal arteries occlusion for 45 min followed by 24 h of reperfusion. Blood samples were collected for biochemical analysis and finally liver samples were preserved for future histological examination. The renal ischaemic challenge resulted in major histological damages of the liver (p<0.001), which were associated with increased levels of creatinine, Blood Urea Nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) during reperfusion period (all p<0.001). In RC+I/R group, the histological damage to the liver was improved (p<0.001) along with increased in plasma creatinine, BUN, ALT and AST being smaller than those of the non-treated rats (p<0.001). Rosa canina exhibited a hepatoameliorative effect against renal ischemia/reperfusion-induced lesions.
PDF Fulltext XML References Citation

How to cite this article

F. Gholampour and S.M. Owji, 2013. Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats. International Journal of Zoological Research, 9: 58-65.

DOI: 10.3923/ijzr.2013.58.65

URL: https://scialert.net/abstract/?doi=ijzr.2013.58.65

Related Articles

Berberine Improves Kidney Injury Following Renal Ischemia Reperfusion in Rats
Damage Pattern as a Function of Various Types of Radiation
Soybean Extract Antioxidant Protective Activity Against Copper-Induced Cytotoxicity
Hyperlipidemia Enhanced Oxidative Stress and Inflammatory Response Evoked by Renal Ischemia/Reperfusion Injury
Anti-Oxidative Effect of Simvastatin in Liver and Lung Tissue after Hepatic Ischemia/Reperfusion in Rat
Antioxidant Effect of Curcumin Extracts in Induced Diabetic Wister Rats

Leave a Comment


Your email address will not be published. Required fields are marked *

Useful Links

  • Journals
  • For Authors
  • For Referees
  • For Librarian
  • For Socities

Contact Us

Office Number 1128,
Tamani Arts Building,
Business Bay,
Deira, Dubai, UAE

Phone: +971 507 888 742
Email: [email protected]

About Science Alert

Science Alert is a technology platform and service provider for scholarly publishers, helping them to publish and distribute their content online. We provide a range of services, including hosting, design, and digital marketing, as well as analytics and other tools to help publishers understand their audience and optimize their content. Science Alert works with a wide variety of publishers, including academic societies, universities, and commercial publishers.

Follow Us
© Copyright Science Alert. All Rights Reserved