Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats

Research Article

**Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats**

Recent studies have shown remote effects of renal Ischemia/Reperfusion (I/R) injury on the liver. Furthermore, I/R injury is correlated with the generation of Reactive Oxygen Species (ROS). This study investigated the effect of Rosa canina on the hepatic dysfunction and histological damage induced by renal ischaemia/ reperfusion at an early stage. There were three groups (n = 10), in which rats received orally 7 days before induction of ischemia, extract of Rosa canina (500 mg kg^-1) in RC+I/R group and distilled water in I/R group. In sham group, the renal arteries were not occluded and distilled water was administered orally 7 days before surgery. Renal ischemia was induced by both renal arteries occlusion for 45 min followed by 24 h of reperfusion. Blood samples were collected for biochemical analysis and finally liver samples were preserved for future histological examination. The renal ischaemic challenge resulted in major histological damages of the liver (p<0.001), which were associated with increased levels of creatinine, Blood Urea Nitrogen (BUN), alanine aminotransferase (ALT) and aspartate aminotransferase (AST) during reperfusion period (all p<0.001). In RC+I/R group, the histological damage to the liver was improved (p<0.001) along with increased in plasma creatinine, BUN, ALT and AST being smaller than those of the non-treated rats (p<0.001). Rosa canina exhibited a hepatoameliorative effect against renal ischemia/reperfusion-induced lesions.

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F. Gholampour and S.M. Owji, 2013. Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats. International Journal of Zoological Research, 9: 58-65.

DOI: 10.3923/ijzr.2013.58.65

URL: https://scialert.net/abstract/?doi=ijzr.2013.58.65

International Journal of Zoological Research

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F. Gholampour

S.M. Owji

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Research Article

**Liver Ameliorative Effects of the Hydroalcohol Extract of Rosa canina L. Fruit against Ischemic Acute Renal Failure-induced Hepatic Damage in Wistar Rats**

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