Abstract:
This study was done to determine the effects of subacute
exposure of Peracetic acid on Hematological indices in Wistar rats. In
this study 18 male Wistar rats divided to two experimental and one control
groups. PAA with 99% purity purchased. Then 0.2 and 2 mL of PAA dissolved
in 100 mL drinking water. Animals in Treatment Group 1 and 2 received
0.2% PAA daily for 4 weeks and 2% PAA daily for 4 weeks, respectively.
After the animals had been sacrificed hematological parameters examined.
Experimental results concerning this study were evaluated using SPSS v.11.5
and expressed as Mean ±SD p<0.05 was considered significant.
Mean ±SD of WBC of groups 1 (2.45 ±0.77) and 2 (3.63 ±0.23)
decreased significantly as compared with control group (5.3 ±0.57).
RBC in control and 1, 2 groups were 8.34 ±0.39, 7.48 ±0.11
and 7.61 ±0.46, respectively. Also HCT and PLT decreased significantly
in groups 1 and 2 as compared with control group. This study showed that
oral consumption of Peracetic acid with concentration 0.2, 2% for 4 weeks
can cause decrease hematological parameter in animal model.
Mohammad Jafar Golalipour, Anneh Mohammad Gharravi, Abbas Ali Keshtkar and Abdoljalal Marjani, 2008. The Effects of Subacute Exposure of Peracetic Acid on Hematological Indices in Wistar Rats. International Journal of Zoological Research, 4: 176-180.
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