Background and Objective: The use of antibiotics is associated with problems such as the presence of residues in eggs and meat and the development of bacterial resistance. These concerns have resulted in the search for phytochemical from plants such as Moringa oleifera leaf. The leaves of Moringa oleifera have been regularly incorporated into feed to improve poultry production but the profitability of this, in modern poultry production, has not been evaluated. This study, therefore, evaluated the financial implications of the use of Moringa oleifera leaves in poultry feed. Materials and Methods: A total of 600 day-old Isa brown chicks were assigned to 3 dietary treatment groups of M₀ (0% of Moringa oleifera leaves), M₁ (1% of Moringa oleifera leaves) and M₂ (2% of Moringa oleifera leaves) from day-old to 280 day of age. Production and financial data were subjected to financial analyses using feed conversion ratio, margin approach, return on investment and break-even yield methods. Results: The study showed that there was a better profitability in the birds fed with the diet containing 1% leaves having 11.04% more income and 14% return on investment than those of M₀. This improved performance was associated to the better feed conversion ratio and high egg production of the birds fed diet containing 1% leaves when compared with those fed 2% Moringa leaves. Conclusion: It was concluded that the use of Moringa oleifera leaf as a prebiotic in a poultry diet improved production performance and profit margin of hens.