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Pharmacokinetics and Bioequivalence of Two Norfloxacin Oral Dosage Forms (Vapcotril - 10%® and Mycomas 10%®) in Healthy Broiler Chickens |
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Ehab A. Abu - Basha,
Saad M. Gharaibeh,
Alaeldein M. Abudabos,
Ahmad F. Shunnaq and Ahmad M. Al - Majali |
Abstract:
A pharmacokinetic and bioequivalence evaluation of two norfloxacin oral solutions
was carried out in healthy broiler chickens after oral administration according
to a single dose, randomized, parallel-experimental design. The two formulations
were: Vapcotril-10%® (Vapco, Jordan) as a test product and Mycomas 10%®
(Univet, Ireland) as a reference product. The chickens were allotted into 3 equal
groups (8 chickens/group). Chickens of group 1 and 2 were given a single oral
dose of Vapcotril-10%® and Mycomas 10%® at a dose level of 16 mg/kg body
weight (bw), respectively after an overnight fasting. Chickens of group 3 were
given a single intravenous dose of norfloxacin to calculate the systemic bioavailability.
Serial blood samples were collected from the left brachial or cutaneous ulnar
veins at different time points post drug administration. Norfloxacin concentrations
in chicken plasma were determined using a microbiological assay and Klebsiella
pneumoniae ATCC 10031 as a test organism. The pharmacokinetics analysis of the
data was performed using non-compartmental analysis based on statistical moment
theory (SMT) with the help of computerized WinNonlin program (Version 5.2, Pharsight,
CA, USA). The maximum plasma concentration (Cmax), time to reach peak concentration
(tmax), area under plasma concentration-time curve (AUC0-12h and AUC0-inf), elimination
half-life (t1/2beta) and systemic bioavailability (F) were. 4.94 ± 0.06
and 3.88 ± 0.07 μg/ml, 1.0 and 2.0 h, 21.60 ± 0.54 and 20.51
± 0.39 μg.h/ml, 25.40 ± 0.76 and 23.40 ± 0.69 μg.h/ml,
4.49±0.13 and 3.87±0.21h, 50 and 47.5% for Vapcotril-10%® and
Mycomas 10%®, respectively. The 90% confidence interval for test: reference
ratio of the AUC0-12h (99.53-111.15), AUC0-inf (100.9-116.72) and Cmax (122.69-132.15)
was within the EMEA bioequivalence acceptance range of 80%–125% for the
AUC and 75-133 for the Cmax. In conclusion, Vapcotril-10%® is bioequivalent
to Mycomas 10%® and can be used as interchangeable therapeutic agents in veterinary
medicine practice.
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How to cite this article:
Ehab A. Abu - Basha, Saad M. Gharaibeh, Alaeldein M. Abudabos, Ahmad F. Shunnaq and Ahmad M. Al - Majali, 2008. Pharmacokinetics and Bioequivalence of Two Norfloxacin Oral Dosage Forms (Vapcotril - 10%® and Mycomas 10%®) in Healthy Broiler Chickens. International Journal of Poultry Science, 7: 289-293.
DOI: 10.3923/ijps.2008.289.293
URL: https://scialert.net/abstract/?doi=ijps.2008.289.293
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