Does Hsp70 Play a Protective Role in Tibial Dyschondroplasia?


	International Journal of Poultry Science
	Year: 2004 \| Volume: 3 \| Issue: 3 \| Page No.: 238-241 DOI: 10.3923/ijps.2004.238.241

Does Hsp70 Play a Protective Role in Tibial Dyschondroplasia?

Gesiane Ribeiro , Juliana C. Bellam , Marcos Macari , Jesus A. Ferro and Joao Martins Pizauro Junior

Abstract: Hsp70 was found in both normal and tibial dyschondroplasia-affected chickens suggesting that Hsp70 is expressed constitutively in the growth plate. Although the Hsp 70 content does not change significantly among the groups with lesion`s degree I to III, a decrease in the amount of total protein in the tibial growth plate of chickens with tibial dyschondroplasia was observed. There was a significant difference in the levels of Hsp70 in the growth plate of the tibia (P<0.001) between lesion of intermediary degree and lesion of severe degree. The enhancement of compressive forces in the articular cartilage might induce the chondrocytes to express induced heat-shock protein (Hsp) 70, as a defense mechanism in bone cellular survival up to score levels III. The possibility that Hsp70 is able, depending lesion`s severity, to protect and block the chondrocyte death up to score levels III, but it fails on severe lesions (degree IV), is discussed.

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How to cite this article:

Gesiane Ribeiro , Juliana C. Bellam , Marcos Macari , Jesus A. Ferro and Joao Martins Pizauro Junior , 2004. Does Hsp70 Play a Protective Role in Tibial Dyschondroplasia?. International Journal of Poultry Science, 3: 238-241.

DOI: 10.3923/ijps.2004.238.241

URL: https://scialert.net/abstract/?doi=ijps.2004.238.241

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