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International Journal of Pharmacology
  Year: 2022 | Volume: 18 | Issue: 8 | Page No.: 1605-1612
DOI: 10.3923/ijp.2022.1605.1612
 
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Non-Insulin Secretion Relative Hypoglycemic Effect of Neonatal Streptozotocin-induced Diabetic Rats by Gavage Feeding Antrodia cinnamomea (Agaricomycetes)

Bing-Rong Ji, Chi-Wen Huang , Ying-I Chen , Wai-Jane Ho , Shu-Wei Chang , Shih-Liang Chang and Chin-Hsien Chang

Abstract:
Background and Objective: Antrodia cinnamomea (AC) is an endemic medicinal fungus in Taiwan that has been shown to have anti-insulin resistance activity in previous studies. However, the therapeutic mechanism of AC in diabetes is unclear. The purpose of this study was the first time to determine the hypoglycemic effects of AC in a neonatal STZ-induced diabetic rat, a partial insulin deficiency state while exploring the impact of the plasma FFA level and insulin signal pathway. Materials and Methods: The neonatal STZ-induced (T2D) rats were randomly assigned to two experimental groups (EGs: AC 200 and AC 500) where they had gavage feeding of 200 or 500 mg kg–1 AC, respectively and one control group (CG) where saline was orally administered. Blood samples were collected from the femoral vein to investigate plasma glucose, insulin and FFA levels. Results: The data showed that AC decreased plasma glucose levels at 60 min, while their plasma free fatty acid (FFA) levels were also lowered significantly (p<0.01). However, there were no significant elevations in the plasma insulin levels of the two experimental groups (EGs). Also, the levels of insulin signalling proteins (IRS-1, GLUT-4 and PI3K) were significantly elevated after administration of AC 500 mg kg–1 (p<0.05). Conclusion: The hypoglycemic effect of AC in neonatal STZ-induced diabetic rats with no significant elevation of plasma insulin may be due to decrease plasma FFA levels and increased expression of intracellular insulin signalling proteins (IRS-1, GLUT-4 and PI3K).
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How to cite this article:

Bing-Rong Ji, Chi-Wen Huang, Ying-I Chen, Wai-Jane Ho, Shu-Wei Chang, Shih-Liang Chang and Chin-Hsien Chang, 2022. Non-Insulin Secretion Relative Hypoglycemic Effect of Neonatal Streptozotocin-induced Diabetic Rats by Gavage Feeding Antrodia cinnamomea (Agaricomycetes). International Journal of Pharmacology, 18: 1605-1612.

DOI: 10.3923/ijp.2022.1605.1612

URL: https://scialert.net/abstract/?doi=ijp.2022.1605.1612

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