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International Journal of Pharmacology
  Year: 2022 | Volume: 18 | Issue: 7 | Page No.: 1482-1492
DOI: 10.3923/ijp.2022.1482.1492
 
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The Regenerated Capacity of Curcumin in the Migration of Epidermal Stem Cells Promotes Skin Wound Healing in a Wistar Rat

Hana H. Mustafa, Snur M.A. Hassan, Omed Omer Rahim, Adel Jabbar Hussein, Dana Omer Ismaeel and Nadia A. Salih

Abstract:
Background and Objective: Turmeric contains a polyphenol called curcumin, which is similar to stem cells in that it can renew identical cells and preserve proliferation and multipotency. Curcumin’s anti-inflammatory and stemness properties as well as regenerative benefits, were investigated in this study. Materials and Methods: Thirty Wistar rats were randomly assigned into five groups (n = 6), negative-control group, treated with normal saline only, curcumin-treated I group, applied topically with curcumin for 7 days, curcumin-treated II group for 14 days, curcumin-treated III group for 21 days and curcumin-treated IV group for 28 days. Wound healing was assessed on days 7, 14, 21 and 28 when skin-wounded tissue were prepared and stained with H&E, Masson’s trichrome special stain and CD34 marker for immunohistochemistry (IHC) utilization. Results: The curcumin decreased granulation tissue intensity vs. the control group on days 7 and day 14. Curcumin significantly reduced the mean of angiogenesis vs. the negative-control group. However, curcumin significantly improves epidermal thickening vs. the negative-control group (score 1 vs. 2, p<0.05), respectively at days 21 and 28. Curcumin improves the collagen fibre, on day 21 as fascicle vs. mixed when compared to the negative-control group. While, on days 21 and 28 the mature collagen was profoundly deposited vs. moderately in the curcumin vs. control groups. Conclusion: we conclude that curcumin significantly accelerated the healing course via modulation in the amount, maturation and arrangement of collagen fibre. Curcumin had a putative regenerative property upon upregulation of CD34 as epidermal stem cell marker expression in epidermis and hair follicles.
Citation
How to cite this article:

Hana H. Mustafa, Snur M.A. Hassan, Omed Omer Rahim, Adel Jabbar Hussein, Dana Omer Ismaeel and Nadia A. Salih, 2022. The Regenerated Capacity of Curcumin in the Migration of Epidermal Stem Cells Promotes Skin Wound Healing in a Wistar Rat. International Journal of Pharmacology, 18: 1482-1492.

DOI: 10.3923/ijp.2022.1482.1492

URL: https://scialert.net/abstract/?doi=ijp.2022.1482.1492

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