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International Journal of Pharmacology

Year: 2021 | Volume: 17 | Issue: 5 | Page No.: 328-338
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Authors

Li Chen

Yi Yan

Zhujuan Li

Hua Li

Hua Li

Keywords

Research Article

Hesperidin Reduces Ovary Toxicity Induces by Cyclophosphamide in Female Rats via Anti-inflammatory and Antioxidant Effects

Li Chen, Yi Yan, Zhujuan Li and Hua Li Hua Li's LiveDNA
Background and Objective: Cyclophosphamide commonly used as a chemotherapeutic agent and used for treating various cancers, including neck, head, breast, colon, testis, bladder, cervical and renal. Cyclophosphamide induced toxic effects such as cause ovary cancer. Hesperidin showed the anti-inflammatory effect and in this current experimental study, we estimate the ovary protective effect of hesperidin against the cyclophosphamide (CP) induced ovarian cancer via an anti-inflammatory pathway. Materials and Methods: Swiss Wistar rat was used for experimental study and subcutaneous injection of cyclophosphamide was used to induce the ovary cancer and received the dose-dependently treatment of hesperidin. Bodyweight and ovary weight was determined at the end of the study. The antioxidant parameter in the ovary tissue and serum were estimated. Hormonal assays were estimated at the end of the study. Inflammatory, cytokines and apoptosis parameters were also estimated. Results: Hesperidin significantly (p<0.001) increased body weight as well as decreased the ovarian tumour. Hesperidin significantly altered the antioxidant levels in the ovary tissue and serum in a dose-dependently manner. It also reduced the biochemical parameters such as myeloperoxidase (MPO) and Nitric Oxide (NO). Hesperidin significantly (p<0.001) down-regulated the cytokines viz., interleukin-6 (IL-6), Tumour Necrosis Factor-α (TNF-α), interleukin-1β (IL-1β); inflammatory mediators such as cyclooxygenase-2 (COX-2), Nitric Oxide Synthase (iNOS)and apoptosis parameters such as caspase-3 and Bcl-2. Conclusion: We can say that hesperidin considerably reduced ovary cancer via an anti-inflammatory mechanism.
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