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International Journal of Pharmacology

Year: 2021 | Volume: 17 | Issue: 5 | Page No.: 319-327
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Authors

Ismaeel Bin-Jaliah

Ismaeel Bin-Jaliah

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Research Article

Quercetin Inhibits Chronic Stress-Induced Depression Associated with the Inhibition of Nitrosative Stress and Apoptosis

Ismaeel Bin-Jaliah Ismaeel Bin-Jaliah's LiveDNA
Background and Objective: Exposure to chronic stress is harmful to vital organs such as the brain and the heart. The potential inhibitory effects of the polyphenolic compound quercetin on Chronic Unpredictable Stress (CUS)-induced depression and biomarkers of brain injury associated with the inhibition of Nitrosative Stress (iNOS) and the apoptotic axis p53-Bax-caspase-3 has not been investigated before. Materials and Methods: Rats were either exposed to a variety of unpredictable stressors daily before being sacrificed after 3 weeks or were treated for 3 weeks with quercetin (50 mg kg–1 b.wt./day). Animals were then culled and brain tissues were harvested. Results: CUS significantly (p<0.05) induced iNOS, MDA, p53, Bax and caspase-3, which were significantly inhibited by quercetin. Whereas, quercetin significantly increased brain tissue levels of SOD and Bcl-2. In addition, CUS caused a significant increase in animal immobility and a decrease in climbing ability and sucrose consumption, which were reverted by quercetin. Furthermore, a significant (p<0.0001) correlation between either cerebral cortex brain injury and biomarkers of apoptosis and survival, p53 and Bcl-2, or between p53 and Bcl-2 and biomarkers of nitrosative stress and depression were observed. Conclusion: Quercetin protects against CUS-induced cerebral cortex injury and depression, which is associated with the inhibition of the p53-Bax-caspase-3 axis and biomarkers of nitrosative and oxidative stress.
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