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International Journal of Pharmacology

Year: 2021 | Volume: 17 | Issue: 5 | Page No.: 262-270
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Authors

Alariqi Reem

Rokayya Sami

Rokayya Sami

Marwa Y.F. Koko

Abeer Essam Noman

Yousif A. Algabri

Raj Aditya Kumar

Ebtihal Khojah

Zhao-Hua Zhong

Keywords

Background and Objective: A comprehensive study of Pseudomonas aeruginosa proteomics found that 25% of proteins are retained as hypothetical proteins whose functions have not yet been ultimately determined. In this study, it’s attempted to assign a particular role to one such hypothetical protein PA2373 for which no experimental knowledge is currently available. Materials and Methods: To achieve this, the newest versions of bioinformatics tools was applied that provide various information, such as regarding amino acid sequences, protein families, sequence-function relationships and motifs. To identify homologous proteins, sequence similarities were searched using accessible bioinformatics databases. Results: Obtained results showed that PA2373 has two functional domains, including VI_Rhs_Vgr and 5 superfamilies. Functional annotation showed that PA2373 could be a Vgr protein and type VI secretion system. In addition, protein-protein interactions of selected hypothetical proteins show that certain functional partners play a significant role in pathogen survival. Conclusion: This study's findings may help better understand the mechanisms of virulence, drug resistance and pathogenesis of P. aeruginosa infections and to innovate the treatment strategies subsequently.
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How to cite this article

Alariqi Reem, Rokayya Sami, Marwa Y.F. Koko, Abeer Essam Noman, Yousif A. Algabri, Raj Aditya Kumar, Ebtihal Khojah and Zhao-Hua Zhong, 2021. Functional and Structural Annotation of a Hypothetical Protein (PA2373) from Pseudomonas aeruginosa PA01. International Journal of Pharmacology, 17: 262-270.

DOI: 10.3923/ijp.2021.262.270

URL: https://scialert.net/abstract/?doi=ijp.2021.262.270

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