Submit Manuscript

International Journal of Pharmacology

Year: 2020 | Volume: 16 | Issue: 8 | Page No.: 529-541
Facebook Twitter Digg Reddit Linkedin StumbleUpon E-mail

Article Trend

Total views 454

Authors

Talha Jawaid

Talha Jawaid

Kalpana

Mehnaz Kamal

Mehnaz Kamal

Nitin Verma

Nitin Verma

Osama A. Alkhamees

Ali M. Alaseem

Saud M. Alsanad

Keywords

Background and Objective: Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder characterized by loss of memory due to phosphorylation of tau protein, neurofibrillary lesions composed of the β-amyloid peptide and aberrant oxidative stress. The objective is to study the combined neuroprotective effect of Selegiline with Piracetam against scopolamine and streptozotocin (STZ)-induced memory impairment in animals. Materials and Methods: This study was designed to investigate the synergistic neuroprotective effect of Selegiline with Piracetam by use of scopolamine and STZ model of memory impairment using the Morris water maze for the assessment of learning and memory. Various biochemical parameters such as acetylcholinesterase activity (AChE) as a marker of cholinergic activity, malondialdehyde (MDA) a marker of lipid peroxidation and glutathione (GSH) a marker of oxidative stress were estimated. Gene expression was also performed by RT-PCR and western blot test. Results: There were a significant decrease in MDA and AChE level and increase in GSH level as compared to the disease control group in Selegiline with Piracetam. In the present study, Bax and Bak mRNA (proapoptotic) were down-regulated, while Bcl-2 mRNA and protein which are antiapoptotic were up-regulated in Selegiline with Piracetam group opposite to the STZ group. Also, p53 expression in the given experiment was appreciably reduced in Selegiline with Piracetam group. Conclusion: The present study indicates that the administration of scopolamine and STZ cause a decline in memory function which is significantly improved by the treatment of selegiline with piracetam. The combined effect of selegiline with piracetam was found to be therapeutically more effective than the individual administration.
PDF Fulltext XML References Citation

How to cite this article

Talha Jawaid, Kalpana, Mehnaz Kamal, Nitin Verma, Osama A. Alkhamees, Ali M. Alaseem and Saud M. Alsanad, 2020. Neuroprotective Effects of Co-Administration of Selegiline with Piracetam on Cognitive Impairment: Involvement of NR2B, NR1 and Bax Signaling Pathway. International Journal of Pharmacology, 16: 529-541.

DOI: 10.3923/ijp.2020.529.541

URL: https://scialert.net/abstract/?doi=ijp.2020.529.541

Leave a Comment

Your email address will not be published. Required fields are marked *