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Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats |
Hassan Elgebaly,
Mousa Germoush,
Nermeen Mosa,
Fatin Zahou,
Ahmed Soffar,
Nasser Alotaibi,
Moath Qarmush,
Omnia Hussein,
May Bin-Jumah  ,
Emad Hassanein,
Rene Hernandez-Bautista and Ayman M. Mahmoud |
Abstract:
Background and Objective: Diabetes Mellitus (DM) is a major healthcare problem worldwide and considerable evidence proved its negative impact on the male reproductive system. Adenium obesum is an interesting medicinal plant with a wide range of bioactivities. The current study examined the protective effects of A. obesum flower extract (AOE) on testicular injury in streptozotocin (STZ)-induced type I diabetic rats. Materials and Methods: Diabetes was induced by a single injection of 50 mg kg–1 STZ. Diabetic rats received 250 and 500 mg kg–1 AOE for 21 days and samples were collected for analysis. Results: As compared to the diabetic control rats, treatment with AOE increased serum testosterone, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels, decreased testicular thiobarbituric acid reactive substances (TBARS) content, effectively enhanced reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Additionally, AOE effectively inhibited diabetes-induced testicular tissue injury and prevented inflammatory and apoptotic responses manifested by decreased TNF-α, IL-6 and Bax and increased Bcl-2. Conclusion: These results demonstrated that AOE mitigates testicular injury, oxidative stress, inflammatory response and apoptotic cell death in STZ-induced diabetic rats.
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How to cite this article:
Hassan Elgebaly, Mousa Germoush, Nermeen Mosa, Fatin Zahou, Ahmed Soffar, Nasser Alotaibi, Moath Qarmush, Omnia Hussein, May Bin-Jumah, Emad Hassanein, Rene Hernandez-Bautista and Ayman M. Mahmoud, 2020. Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats. International Journal of Pharmacology, 16: 310-318.
DOI: 10.3923/ijp.2020.310.318
URL: https://scialert.net/abstract/?doi=ijp.2020.310.318
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