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International Journal of Pharmacology

Year: 2020 | Volume: 16 | Issue: 4 | Page No.: 310-318
DOI: 10.3923/ijp.2020.310.318

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Authors


Hassan Elgebaly

Country: Saudi Arabia

Mousa Germoush

Country: Saudi Arabia

Nermeen Mosa

Country: Saudi Arabia

Fatin Zahou

Country: Saudi Arabia

Ahmed Soffar

Country: Saudi Arabia

Nasser Alotaibi

Country: Saudi Arabia

Moath Qarmush

Country: Saudi Arabia

Omnia Hussein

Country: Egypt

May  Bin-Jumah

May Bin-Jumah

LiveDNA: 966.25342

Emad Hassanein

Country: Egypt

Rene Hernandez-Bautista

Country: Germany

Ayman M.  Mahmoud

Ayman M. Mahmoud

LiveDNA: 20.6186

Keywords


  • Desert rose
  • oxidative injury
  • inflammation
  • antioxidants
  • phenolics
  • diabetes
  • testosterone
  • apoptosis
Research Article

Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats

Hassan Elgebaly, Mousa Germoush, Nermeen Mosa, Fatin Zahou, Ahmed Soffar, Nasser Alotaibi, Moath Qarmush, Omnia Hussein, May Bin-Jumah May  Bin-Jumah's LiveDNA, Emad Hassanein, Rene Hernandez-Bautista and Ayman M. Mahmoud Ayman M.  Mahmoud's LiveDNA
Background and Objective: Diabetes Mellitus (DM) is a major healthcare problem worldwide and considerable evidence proved its negative impact on the male reproductive system. Adenium obesum is an interesting medicinal plant with a wide range of bioactivities. The current study examined the protective effects of A. obesum flower extract (AOE) on testicular injury in streptozotocin (STZ)-induced type I diabetic rats. Materials and Methods: Diabetes was induced by a single injection of 50 mg kg–1 STZ. Diabetic rats received 250 and 500 mg kg–1 AOE for 21 days and samples were collected for analysis. Results: As compared to the diabetic control rats, treatment with AOE increased serum testosterone, Follicle-Stimulating Hormone (FSH) and Luteinizing Hormone (LH) levels, decreased testicular thiobarbituric acid reactive substances (TBARS) content, effectively enhanced reduced glutathione (GSH) content and superoxide dismutase (SOD) activity. Additionally, AOE effectively inhibited diabetes-induced testicular tissue injury and prevented inflammatory and apoptotic responses manifested by decreased TNF-α, IL-6 and Bax and increased Bcl-2. Conclusion: These results demonstrated that AOE mitigates testicular injury, oxidative stress, inflammatory response and apoptotic cell death in STZ-induced diabetic rats.
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How to cite this article

Hassan Elgebaly, Mousa Germoush, Nermeen Mosa, Fatin Zahou, Ahmed Soffar, Nasser Alotaibi, Moath Qarmush, Omnia Hussein, May Bin-Jumah, Emad Hassanein, Rene Hernandez-Bautista and Ayman M. Mahmoud, 2020. Adenium obesum Flowers Extract Mitigates Testicular Injury and Oxidative Stress in Streptozotocin-induced Diabetic Rats. International Journal of Pharmacology, 16: 310-318.

DOI: 10.3923/ijp.2020.310.318

URL: https://scialert.net/abstract/?doi=ijp.2020.310.318

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