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International Journal of Pharmacology
  Year: 2019 | Volume: 15 | Issue: 3 | Page No.: 301-310
DOI: 10.3923/ijp.2019.301.310
 
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Toxicity, Teratogenicity and Anti-cancer Activity of α-solanine: A Perspective on Anti-cancer Potential

Adriana Ordóñez- Vásquez, Víctor Aguirre- Arzola, Myriam Angélica De la Garza-Ramos , Víctor Hugo Urrutia-Baca and Fernando Suárez-Obando

Abstract:
The α-Solanine is a glycoalkaloid metabolite produced by solanaceae species, important plant food in the human nutrition. This α-solanine is highly toxic to animals and humans and has been indicated as a risk factor for developing congenital malformations. However, recent studies suggest that α-solanine possesses anti-microbial and anti-tumor activities. The aim of this review was to summarize the main properties of α-solanine, its toxicity and teratogenicity in animal models and the main findings reported about anti-cancer activity against various cancer cell lines in in vitro assays. Key α-solanine mechanisms of action are presented alongside arising interdisciplinary research, connecting agricultural sciences and medicine. Data presented in this review, may assisted in preventing toxic effects of α-solanine and promote research about its potential use in the treatment and management of human cancers.
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How to cite this article:

Adriana Ordóñez- Vásquez, Víctor Aguirre- Arzola, Myriam Angélica De la Garza-Ramos, Víctor Hugo Urrutia-Baca and Fernando Suárez-Obando, 2019. Toxicity, Teratogenicity and Anti-cancer Activity of α-solanine: A Perspective on Anti-cancer Potential. International Journal of Pharmacology, 15: 301-310.

DOI: 10.3923/ijp.2019.301.310

URL: https://scialert.net/abstract/?doi=ijp.2019.301.310

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