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International Journal of Pharmacology

Year: 2019 | Volume: 15 | Issue: 2 | Page No.: 177-188
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Authors

Ahmed M. S. Hussein

Karem Aly Fouda

Karem Aly Fouda

Ahmed Noah Badr

Ahmed Noah Badr

Adel G. Abdel-Razek

Keywords

Background and Objective: Aflatoxin B1 (AFB1), a pre-carcinogenic and toxic compound which contaminates foodstuffs and edible tissues, is associated with oxidative stress and hepatotoxicity. This investigation aimed to assess the counteractive role of ethanol (EWP), petroleum ether (PWP) and n-hexane (HWP) white pepper extracts for oxidative stress and hepatotoxicity induced by AFB1 in a rat model. Materials and Methods: Concentrated white pepper extracts (WPEs) estimated for total phenolic, total flavonoids, anti-oxidant and anti-fungal activities. Otherwise, the fatty acids composition of white pepper was analyzed. Forty-eight male albino rats were divided into 8 groups, negative and positive AFB1 groups and the other 6 groups were treated to evaluate the WPEs biological effects either in the AFB1 presence or absence. Results: The results elucidated that WPEs suppressed both the raising of aminotransferases enzymes (alanine and aspartate) and alkaline phosphatase and the reduction of total protein. The WPEs combat the negative impact of AFB1 on kidney functions and alleviated AFB1 mediated oxidative stress either in plasma or liver. Also, it relieved the AFB1 mediated lipid disturbance and hemoglobin reduction and exhibited antioxidant and antifungal activities. Conclusion: It was concluded that the extracts gave a counteractive role for oxidative stress which support the hepatotoxicity induced by AFB1 presence.
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