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Beneficial Effects of Lipoic Acid on Post-burn Hypertrophic
Scarring Model |
Chunhu Zhao,
Lingyun Dai,
Jing Wang,
Yu Jian,
Zujun Mei,
Xufeng Pei,
Xiaoqing Xiong,
Wensheng Yuan and Fengxue Wu  |
Abstract:
Background and Objective: Hypertrophic scar (HTS) is a fibroproliferative disorder which develops from thermal or traumatic injury. The
present experiment was intended to evaluate the beneficial effect (anti-scarring) of alpha-lipoic acid (ALA) against post burn
hyperscarring rabbit ear model. Materials and Methods: Rabbits were separated into four groups as negative control- HTS group rabbits
were induced with full thickness burn wound using a 7 mm red hot plate (100°C). While, the HTS induced rabbits were treated topically
with 5, 10 and 20 % ALA, respectively from the 8th day until 28 days. Data were analyzed using one-way ANOVA (analysis of variance) with
a significance level of 5%. Results: The contents of collagen (type I and III), as well as glycosaminoglycans (hydroxyproline and
hexosamine),were significantly decreased upon treatment with a different dose of ALA. All the irregular/abnormal histological changes
were reverted to normal (regular collagen fibres and lesser fibroblast) on addition with ALA in dose concentration fashion. Topical
application of ALA for 21 days considerably lowered the scar elevation index (SEI). Moreover, treatment with ALA could markedly up
regulate or down-regulate the protein expressions of matrix metalloproteinase-1(MMP-1) and transforming growth factor beta-1 (TGF-β1), respectively. Conclusion: The topical application of ALA could drastically lower the scarring area after a thermal wound in a dosedependent
manner. Hence, ALA can be recommended for treating various injury scar especially post-burn hypertrophic scar with standard
anti-scarring agents.
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How to cite this article:
Chunhu Zhao, Lingyun Dai, Jing Wang, Yu Jian, Zujun Mei, Xufeng Pei, Xiaoqing Xiong, Wensheng Yuan and Fengxue Wu, 2018. Beneficial Effects of Lipoic Acid on Post-burn Hypertrophic
Scarring Model. International Journal of Pharmacology, 14: 733-739.
DOI: 10.3923/ijp.2018.733.739
URL: https://scialert.net/abstract/?doi=ijp.2018.733.739
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