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International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 5 | Page No.: 633-639
DOI: 10.3923/ijp.2018.633.639
 
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Evaluation of Antidepressant Activity of Triptolide in Lipopolysaccharide Induced Depressive like Behavior in Experimental Mice
Lirong Lei, Yan Wu, Shengqiang Lu, Bin Zhao and Yishu Liu

Abstract:
Background and Objective: Depression is a psychiatric disorder and inflammation facilitates the depression. Complexity of symptoms related to depression among different individuals and different therapeutic responses exhibited by the use of available antidepressants show that a need to identify novel antidepressants is there. Thus present study evaluates the effect of Triptolide (TPL) on depressive like behavior induced by lipopolysaccharide (LPS) in mice. Materials and Methods: All the mice were challenged with LPS (0.83 mg kg–1, i.p.) 30 min after the administration of 5 mg kg–1 of TPL. Several behavioral parameters were studied including open field test, forced swim test, tail suspension test and sucrose preference test. The level of pro-inflammatory cytokines and oxidative stress parameters were estimated in the brain tissues of LPS challenged mice. Moreover, level of brain derived neurotrophic factor (BDNF) in the brain tissues and plasma concentration of corticosteroid was estimated in LPS challenged mice. Results: Data given in the study suggested that treatment with TPL attenuates the behavioral parameters affected by LPS in mice. Level of pro-inflammatory cytokines and oxidative stress parameters were significantly decreases in the prefrontal cortex and hippocampus of TPL treated group compared to negative control group. Plasma concentration of corticosteroid significantly decreases and level of BDNF in brain tissue significantly increases in TPL treated group than negative control group of mice. Conclusion: Present study concludes that treatment with TPL attenuates the depressive behavior by decreasing the level of cytokines and oxidative stress parameter in the brain tissues of LPS challenged mice.
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How to cite this article:

Lirong Lei, Yan Wu, Shengqiang Lu, Bin Zhao and Yishu Liu, 2018. Evaluation of Antidepressant Activity of Triptolide in Lipopolysaccharide Induced Depressive like Behavior in Experimental Mice. International Journal of Pharmacology, 14: 633-639.

DOI: 10.3923/ijp.2018.633.639

URL: https://scialert.net/abstract/?doi=ijp.2018.633.639

 
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