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International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 3 | Page No.: 377-383
DOI: 10.3923/ijp.2018.377.383
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A Comparison of Immunomodulatory Monotherapy and Combination Therapy for Recurrent Aphthous Stomatitis
Yuan Xue, Jiyan Liu and Wenfeng Zhao

Background and Objective: Systemic steroids are used to prevent and heal mouth ulcers. However, ulcers often reappear after steroid withdrawal. The toxicity of systemic corticosteroids impedes their chronic use; corticosteroid-sparing agents must be employed instead. Here, the study evaluated the efficacy and safety of levamisole or prednisolone alone and a levamisole/prednisolone combination, in patients with recurrent aphthous stomatitis (RAS). Materials and Methods: Patients with RAS received levamisole 150 mg/day (Group L, n = 100), prednisolone 15 mg/day (Group P, n = 100) or levamisole 150 mg/day plus prednisolone 15 mg/day (Group L+P, n = 100), for 6 months. The study recorded ulcer number and size, pain intensity and serious and non-serious adverse events. The paired samples t-test and chi-squared test were used to define significant between group differences (with 95% confidence intervals). Results: At the end of 6 months, all patients exhibited reductions in both ulcer sizes and pain (both p<0.05). Neither ulcer number nor size differed between patients given combination therapy and those receiving monotherapies (p>0.05 for both). Non-serious adverse events for up to 6 months were more common in patients on the combination therapy than in those receiving the monotherapies (all p<0.05). Conclusion: Therefore, it was concluded that combination therapy and the monotherapies exhibited similar efficacy. However, combination therapy was associated with more adverse events.
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How to cite this article:

Yuan Xue, Jiyan Liu and Wenfeng Zhao, 2018. A Comparison of Immunomodulatory Monotherapy and Combination Therapy for Recurrent Aphthous Stomatitis. International Journal of Pharmacology, 14: 377-383.

DOI: 10.3923/ijp.2018.377.383








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