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International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 8 | Page No.: 1198-1202
DOI: 10.3923/ijp.2018.1198.1202
Foot-shock Stimulation Decreases the Inhibitory Action of ATP on Contractility and End-plate Current of Frog Sartorius Muscle
Ayrat Usmanovich Ziganshin , Rafis Rustemovich Kamaliev, Azat Iskhakovich Gabdrakhmanov, Adel Evgenyevich Khairullin and Sergey Nikolaevich Grishin

Abstract:
Background and Objective: Inhibitory action of ATP on contractions of frog isolated sartorius muscle was shown earlier, while hydrocortisol prevented that effect of ATP. The aim of this study was to investigate whether ATP also inhibits the contractility of sartorius muscle on stress-induced animals. Materials and Methods: The influence of ATP on contractions and end-plate current (EPC) of sartorius muscles isolated from frogs exposed to electric foot-shock stimulation (EFSS) was analyzed. Results: In the muscles of frogs exposed to EFSS, the inhibitory effect of ATP on contractions was significantly decreased and on EPC was abolished. The level of cortisol was much higher in the blood obtained from EFSS animals comparing with control ones. Conclusion: The EFSS has inhibitory action on the effect of ATP on the frog sartorius muscle and that could be due to increase of cortisol blood level.
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How to cite this article:

Ayrat Usmanovich Ziganshin, Rafis Rustemovich Kamaliev, Azat Iskhakovich Gabdrakhmanov, Adel Evgenyevich Khairullin and Sergey Nikolaevich Grishin, 2018. Foot-shock Stimulation Decreases the Inhibitory Action of ATP on Contractility and End-plate Current of Frog Sartorius Muscle. International Journal of Pharmacology, 14: 1198-1202.

DOI: 10.3923/ijp.2018.1198.1202

URL: https://scialert.net/abstract/?doi=ijp.2018.1198.1202

 
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