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International Journal of Pharmacology
  Year: 2018 | Volume: 14 | Issue: 8 | Page No.: 1179-1187
DOI: 10.3923/ijp.2018.1179.1187
Ameliorative Potential of Lagenaria sicereria Extract as Anti-Anxiety Drug in Various Models of Anxiety in Rats
Shuyuan Wang, Shujing Wu, Souravh Bais and Ruihua Hou

Abstract:
Background and Objective: Anxiety is an emotional state with imbalance of neurotransmitters like Gamma Amino Butyric Acid, serotonin and leads to feeling of discomfort, concern or fears to define or undefined objects/situation. The aim of present study was to evaluate the potential effect of Lagenaria sicereria extracts in various models of anxiety in rats. Materials and Methods: Three well established models (Elevated Plus maze, Light Dark and social interaction in rats) were selected for evaluation of anxiety in rats. The protocol was designed by giving drugs for seven days and various behavioral parameters like Time spent in the open and closed arm, No. of entries in each arm, Latency, Time spent in light and dark compartment, No. of crossings, Immobility, Sniffing, Crawling and Aggressive behaviors were evaluated on 1st, 3rd and 7th day of study. The rats were treated at two doses (250 and 500 mg kg–1, p.o.) of methanolic extract of Lagenaria sicereria (MELS) leaf. The dose selections were based on acute toxicity study in mice. The standard drug, Fluoxetine (10 mg kg–1, p.o.) were also given to compare its beneficial effects in anxiety. At the end of an experiment, all animals were subjected to dissection and serotonin and GABA levels were determined in brain tissues. Results: MELS was found to possess a therapeutic effect against anxiety disorder. The Rats treated with 500 mg kg–1, p.o. showed significant changes in behavioral and mobility in all three models during experiment. Conclusion: From the present findings, it was concluded that MELS extracts poss significant anxiolytic effects in rats and its due to modulation of GABA and serotonin level in brain tissues of rats.
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How to cite this article:

Shuyuan Wang, Shujing Wu, Souravh Bais and Ruihua Hou, 2018. Ameliorative Potential of Lagenaria sicereria Extract as Anti-Anxiety Drug in Various Models of Anxiety in Rats. International Journal of Pharmacology, 14: 1179-1187.

DOI: 10.3923/ijp.2018.1179.1187

URL: https://scialert.net/abstract/?doi=ijp.2018.1179.1187

 
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